Smokers who quit show remarkable ability in repairing their metabolite levels that resemble exactly to those of nonsmokers, reveals a new study.
Now in a study appearing in ACS' Journal of Proteome Research, scientists report that certain metabolic changes occur soon after quitting, and these changes could help explain how some ill-effects of smoking might be reversible.
Running can Help People Quit Smoking
People who joined a running group as part of the community-based program were likely to quit smoking. The carbon monoxide level decreased by about one-third.
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‘Along with several others, about 52 metabolites are altered in those individuals who quit smoking. Within two to three months of quitting smoking, lung function begins to improve and the risk of heart attack begins to diminish.’
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Smoking kills more than 7 million people worldwide annually and is one of the most important risk factors for six of world's eight leading causes of premature death, according to the World Health Organization. But, soon after a person quits the body begins to repair some of accumulated damage caused by smoking.
In fact, according to the U.S. Centers for Disease Control and Prevention, within two to three months of quitting, lung function begins to improve and the risk of heart attack begins to diminish.
![Prescription Smoking-Cessation Drug to Quit Smoking may Not Work Wonders]( "Prescription Smoking-Cessation Drug to Quit Smoking may Not Work Wonders")
The introduction of a new prescription smoking-cessation drug varenicline in 2006 had no significant impact on the rate at which US adults quit smoking.
A previous study published in 2013 suggested that metabolic changes which occur after smoking cessation may kick start these physiological improvements.
Building on this work, Nikola Pluym and colleagues sought to hone in on what alterations smoking causes in the body's metabolic pathways and whether any of these changes are reversible after quitting.
The researchers regularly collected blood, urine and saliva samples from male volunteers who were trying to quit smoking up to three months after smoking cessation.
To minimize nutritional effects on metabolism, the researchers strictly controlled the volunteers' diets during four in-patient stays.
To ensure compliance, they measured levels of carbon monoxide and cotinine, a nicotine metabolite which can be detected in urine and saliva over several days after someone has smoked.
In the study, the researchers analyzed the experimental samples with an untargeted metabolic fingerprinting approach.
Overall, the researchers identified 52 metabolites that were significantly altered after the subjects stopped smoking, including several that showed reversible changes toward that of a nonsmoker's metabolic profile.
The team concluded that these compounds could one day be used as biomarkers for smoking-induced biological changes. Moreover, the researchers state that the published method would be also useful for evaluating the benefits, if any, for smokers when switching to new products like electronic cigarettes.
Source: Eurekalert
Prescription Smoking-Cessation Drug to Quit Smoking may Not Work Wonders
The introduction of a new prescription smoking-cessation drug varenicline in 2006 had no significant impact on the rate at which US adults quit smoking.
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A previous study published in 2013 suggested that metabolic changes which occur after smoking cessation may kick start these physiological improvements.
Building on this work, Nikola Pluym and colleagues sought to hone in on what alterations smoking causes in the body's metabolic pathways and whether any of these changes are reversible after quitting.
The researchers regularly collected blood, urine and saliva samples from male volunteers who were trying to quit smoking up to three months after smoking cessation.
To minimize nutritional effects on metabolism, the researchers strictly controlled the volunteers' diets during four in-patient stays.
To ensure compliance, they measured levels of carbon monoxide and cotinine, a nicotine metabolite which can be detected in urine and saliva over several days after someone has smoked.
In the study, the researchers analyzed the experimental samples with an untargeted metabolic fingerprinting approach.
Overall, the researchers identified 52 metabolites that were significantly altered after the subjects stopped smoking, including several that showed reversible changes toward that of a nonsmoker's metabolic profile.
The team concluded that these compounds could one day be used as biomarkers for smoking-induced biological changes. Moreover, the researchers state that the published method would be also useful for evaluating the benefits, if any, for smokers when switching to new products like electronic cigarettes.
Source: Eurekalert
Running May Help You to Quit Smoking: Report
Having difficulty in quitting smoking? Try Running as it can help. Cigarette smoking is responsible for many other cancers and health problems.
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 More Than 3300 People Quit Smoking in Several Cities of Virginia State, USAThe percentage of people who stopped smoking was higher in Norfolk than in neighboring Suffolk and Cambridgeshire and the use of e-cigarettes increased. | Advertisement
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