Advances in Lymphatic Cancer Treatment : Preserving Fertility for a Brighter Future

Patients with advanced Hodgkin's lymphoma now have improved prospects for preserving fertility after treatment, a ground-breaking study led by the German Hodgkin Study Group. The research revealed that the BrECADD chemotherapy regimen significantly better preserves fertility compared to the previous standard, eBEACOPP, without compromising treatment effectiveness (1^✔ ✔Trusted Source
Advances in the treatment of Hodgkin lymphoma: Current and future approaches

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Fertility Preservation for Classic Hodgkin Lymphoma Patients

 “Fertility in patients with advanced-stage classic Hodgkin lymphoma treated with BrECADD versus eBEACOPP: a secondary analysis of the multicentre, randomised, parallel, open-label, phase 3 HD21 Trial“ in the journal The Lancet Oncology.

In the HD21 trial,, patients with advanced classical Hodgkin’s lymphoma received one of two therapies: either the experimental therapy with BrECADD or the previous standard of care eBEACOPP. Three years after treatment was concluded, there were major differences: In the BrECADD group, 95 percent of women and 86 percent of men had normal hormone levels again – compared to 73 percent and 40 percent respectively in the eBEACOPP group. More pregnancies and births were documented after the BrECADD regimen was applied. For men in particular, this means a significantly higher chance of biological paternity after treatment.

Balancing Cancer Care and Family Planning: Hodgkin's Lymphoma Treatment

BrECADD gives young adults with Hodgkin’s lymphoma a better chance of starting a family later in life – with an equally good or even slightly better cure rate,” explains Dr Justin Ferdinandus, Study Physician in the German Hodgkin Study Group (GHSG) and first author of the publication. “The HD21 study is fundamentally changing practice. Our data clearly show that BrECADD is the preferred first-line treatment for patients who wish to have children – at University Hospital Cologne and in the current Onkopedia guideline, this is already the new standard,” adds Dr Karolin Behringer, Study Physician at the GHSG and last author of the study.

The HD21 study is a randomized phase III clinical trial involving over 1,500 participants up to the age of 60 at 233 centres in nine countries. Among other things, the recovery of hormone levels (measured via blood serum levels of follicle-stimulating hormone) were examined along with pregnancies and births after therapy was concluded.

Nurturing Life, Beyond Cancer
Reference:

1. Advances in the treatment of Hodgkin lymphoma: Current and future approaches - (https://pmc.ncbi.nlm.nih.gov/articles/PMC10020509/)

Source-Eurekalert