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Normal Physiology & Mechanism

Normal Physiology & Mechanism

Mechanism of polycystic ovarian syndrome due to hormonal imbalance.

The hormones in our bodies are regulated by two regions of the brain – the hypothalamus and the pituitary gland. Hormones are chemicals that are secreted in miniscule amounts and a very small imbalance in their secretions can lead to different problems that can manifest as diseases. Understanding the cause of polycystic ovaries requires some basic understanding of how the hormones are normally regulated.

In the normal state

Hypothalamus secretes gonadotropin-releasing hormone (GnRH)
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GnRH releases luteinizing hormone (LH) and Follicle-Stimulating Hormone (FSH) from the pituitary gland
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Acts on certain cells of the ovary
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Bring about maturation of the follicle and results in release of eggs

In polycystic ovaries syndrome, the cycle is disturbed. Evaluation of blood serum levels typically reveals elevated LH levels and normal or low FSH levels. Patients also have increased levels of free estrogen (primarily estrone and estradiol) and testosterone levels.

The lack of follicle maturation and the inability to ovulate are likely caused by low levels of follicle stimulating hormone (FSH) , and higher-than-normal levels of androgens (male hormones), produced in the ovary.


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Nida21

I am suffering from PCOD since I was 15 years. I have been taking 'krimpson 35' medicine as prescribed by the doctor. Its been 5 years and I have to take the medicine daily for getting my periods regular. Will I be dependent on medicine all through my life? Does it have any side effect?

c7e4k6h2

I've been dealing with this for over 15 yrs, and yes, you can have kids-I have 2. If you get hold of a GP who won't take it seriously, find another one. I use is 1500mg daily Metformin, 2 iron supplements [Metformin can make you have mal-absorption] daily and a b12 shot monthly, (metformin stops b12 absorption in some cases too). After years of struggle with eating disorders that hospitalized me and almost ruined my health and mental well being, I am at normal weight with moderate diet and excerise regimes. the right drug regime is key, don't let them tell you do nothing until you want to be pregnant or prescribe birth control. Take it seriously- it is easily managed but it is a condition.

c7e4k6h2

I've been dealing with this for over 15 yrs, so I can say, even in extremes, yes, you can have kids. I have 2. If you get hold of a GP who won't take it seriously, find another one. the treatment I use is 1500mg daily [1 at meal times] Metformin, 2 iron supplements (Metformin can make you v tired from malabsorption of iron) daily and a b12 shot monthly, (metformin stops b12 absorption in some cases too). these few hiccups have been nothing compared to what I gained. After years of struggle with eating disorders that hospitalized me and almost ruined my health and mental well being, I am able to maintain a normal weight with moderate diet and excerise regimes. the right drug regime is key, don't let them tell you do nothing until you want to be pregnant or prescribe birth control. There are so many things we know now that this can affect, hormones, depression, kidneys, pancreas, heart. Take it seriously- it is easily managed but it is a condition. Best of luck-

PriyankaR

me too suffering from PCOD from the time i started having periods at the age of 13.now i am 25.will i be able to get pregnant?

Confused34

I was diagnosed with PCOS the gyn says I have nothing to worry about unless I want to get pregnant or worry about getting facial hair. I am not receiving treatment because he said it wasn't serious. Now I am worried he was wrong

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