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Venetoclax : Interaction with Food and Herbs


Interaction of Venetoclax with Food and Herbs - For your own safety It is important to understand and avoid the drug-food interaction and how to take the medication. Drug-food interaction can sometimes cause side effects and can even reduce the efficacy of the drug.
Venetoclax Venetoclax is a BCL-2 (B - cell lymphoma 2) inhibitor which is prescribed for the treatment of a type of white blood cell cancer, chronic lymphocytic leukemia (CLL), in patients whose tumor cells lack a part of the 17th chromosome (a specific gene alteration known as 17p deletion). It is prescribed only for patients who received prior treatment for the cancer. Venetoclax mainly acts by inhibiting the action of the BCL-2 protein present in the cancer cells and kills the abnormal lymphocytes which are present in the blood and the bone marrow.

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Venetoclax Interactions with Food and Herbs

Grapefruit Juice, Seville Oranges and Star Fruit: CYP3A inhibitors like grapefruit juice, seville oranges and starfruit when taken along with venclexta increase the concentration of the serum drug level resulting in side effects like tumor lysis syndrome (fast and abnormal breakdown of cancer cells leading to kidney failure and even death).

St. John's Wort: Intake of St. John's Wort with venetoclax decreases the concentration of the drug and reduces its effectiveness.

Fatty meal: Fatty meal increases the oral bioavailability of venetoclax.

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How to Take the Medication -

Venetoclax comes in the form of a film-coated tablet to be taken once daily by mouth. It should be taken with meals and water. You should take only the recommended amount of the drug. Do not take additional dose on the same day if the drug causes vomiting. Read the prescription leaflet carefully and follow the instructions exactly as directed.
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