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Mercaptopurine : Interaction with Foods, Herbs & Alcohol


Are you taking Mercaptopurine? Are you aware of the dangers of combining Mercaptopurine with certain foods, herbs, or alcohol? Drug-food-interactions are seldom discussed but can lead to undesirable side effects and potentially diminish the efficacy of the medication.

Mercaptopurine Interactions with Food and Herbs

Dairy products: Avoid dairy products such as milk while taking mercaptopurine since dairy products contain xanthine oxidase, an enzyme that may reduce the bioavailability of the drug (1 Trusted Source
De Lemos, M. L., Hamata, L., Jennings, S., & Leduc, T. (2007). Interaction between mercaptopurine and milk.

Go to source
).

Mercaptopurine Interactions with Alcohol

Drinking a small amount of alcohol along with mercaptopurine does not affect the efficacy of the drug (2 Trusted Source
Wikidoc: Mercaptopurine

Go to source
).

When and How to Take Mercaptopurine

  • Mercaptopurine is available in the form of a tablet or suspension to be taken orally (by mouth).
  • You will usually be advised to take it once a day on an empty stomach.
  • Follow the directions exactly as given on the prescription label. Take the medication at the same time every day for better results.
  • Do not exceed or skip a dose. Even if you miss it, take the medication as soon as you remember (3 Trusted Source
    National Library of Medicine: Mercaptopurine MedlinePlus Drug Information.

    Go to source
    ).

References

1. De Lemos, M. L., Hamata, L., Jennings, S., & Leduc, T. (2007). Interaction between mercaptopurine and milk. Journal of oncology pharmacy practice: official publication of the International Society of Oncology Pharmacy Practitioners,13 (4), 237-240. doi:10.1177/1078155207080802https://pubmed.ncbi.nlm.nih.gov/18045784/
2. Wikidoc: Mercaptopurine. https://www.wikidoc.org/index.php/Mercaptopurine#Precautions_with_Alcohol
3. National Library of Medicine: Mercaptopurine MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a682653.html

Drug Name : Mercaptopurine

Mercaptopurine is an antimetabolite, prescribed for acute lymphatic leukemia either alone or with other medications.
We recommend consulting your doctor to verify the information presented on this page or if you need any further clarifications.


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