Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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General Information on Venlafaxine

Generic Name : Venlafaxine

Pronunciation : ven' la fax een

Latest prescription information about Venlafaxine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y49.2 | Therapeutic Classification : Psychotherapeutics

Why is Venlafaxine Prescribed? (Indications)

This medication is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI), prescribed for depression, generalized anxiety disorder, social anxiety disorder, and panic disorder.  It increases serotonin and norepinephrine levels in the brain that help to maintain mental balance.

When should Venlafaxine not to be taken? (Contraindications)

Contraindicated in patients who are taking MAOIs or who have taken MAOIs within 14 days, and hypersensitivity.

What is the dosage of Venlafaxine?

For depression- Initial: 75 mg/day in 2-3 divided doses, increase slowly if needed. Max: 375 mg/day.
For anxiety Extended release- Initial: 75 mg once daily, may increase slowly if needed. Max: 225 mg/day.
For panic disorder- 37.5 mg once daily for 1st 7 days, may increase slowly if needed. Max: 225 mg/day.

How should Venlafaxine be taken?

It comes as a tablet or extended-release capsule to take by mouth. Take tablet 2times/day and extended-release capsule once daily in the morning or evening with food.

What are the warnings and precautions for Venlafaxine?

It may cause moderate to severe liver or kidney problems. Conditions which may be worsened by increase in heart rate.

Caution should be exercised in patients with history of heart attack, bleeding disorder, epilepsy, hypomania or mania, elderly, during pregnancy.

Monitor blood pressure, serum cholesterol regularly.

Monitor closely during early therapy until depression improves due to increased risk of suicide.

Discontinue if seizure develops or increase in seizure frequency.

Patient may develop with increased risk of Serotonin Syndrome with the following symptoms: restlessness, diarrhea, fast heart beat, incoordination, nausea, vomiting. If it is so consult with your healthcare provider.

What are the side effects of Venlafaxine?

  Heart: Widening of blood vessels,high blood pressure, palpitations, fast heart beat, low blood pressure, deep vein blood clot, ECG abnormalities (eg, QT prolongation), irregular heart beat.
  Central Nervous System: Headache, drowsiness, dizziness, sleeplessness, nervousness, weakness, anxiety, tremor, abnormal dreams, agitation, depression, increased muscle tightness, tingling, twitching, abnormal thinking, confusion, loss of memory, impaired coordination and balance, involuntary movements, shock-like electrical sensations.
  Skin: Sweating, rash, itching, redness of the skin, toxic epidermal blistering.
  Eye and ENT: Throat inflammation, abnormal vision, dilation of pupil, taste perversion, sudden eye pressure, eye bleeding.
  Gastrointestinal: Nausea, dry mouth, loss of appetite, constipation, abdominal pain, diarrhea, vomiting, indigestion, flatulence, eructation, increased appetite,bleeding.
  Genitourinary: Abnormal ejaculation, impotence, decreased sexual activity, impaired urination, orgasm disturbance, urinary frequency, albumin in urine, painful menstruation, weak urination, vaginal inflammation, urinary retention.
  Blood:Discoloration of skin, decrease in white blood cell, decrease in platelets, and neutrophils.
  Liver: Liver function abnormalities, liver damage, necrosis, or failure, and fatty liver.
  Metabolic: Weight loss, edema, weight gain
  Respiratory: Inflammation of bronchus, cough increased, difficulty in breathing, interstitial lung disease.
  Miscellaneous: Yawning, chills, flu-like syndrome, infection, accidental injury, chest pain, trauma, joint pain, fever, neck pain, chest pain, birth defect, bleeding, increased prolactin, night sweats, high concentration of eosinophils, kidney failure.

What are the other precautions for Venlafaxine?

Avoid abrupt withdrawal. Withdraw gradually over at least 1 to 2 week.

What are the storage conditions for Venlafaxine?

Oral: Store below 30C. Store it in an airtight container and keep away from children.

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123kenny, Cambodia

I will be arriving in India soon for an extended stay. Is Effexor 150mg, or other strengths, commonly available in India's pharmacies? If so, is a prescription necessary? Approximate cost per capsule? I am not looking for generics, only Effexor. Thank you for your time...k

Mohamed_12345, United Arab Emirates

I was advised to take D-Venz 50 XR . When I took the first tablet , after 3 hours ,started with strong dry cough and after that severe Dry cough which made my Bronchitis no good. After 24 hours ,I got relief slowly and I stopped the D-Venz tab. Any body faces the such experience .Thanks Mohammed ,

kumarkk, India

Iam on veniz xr 75 for 6 months .i am facing low libido can i take stay on for it

ponraj, Sri Lanka

im 50 years old i using venlift od 75mg 1 bd from 2009 till today for depression n anxiety how long want be use this dose and long term taking that capsul any problem me please tell me good answer thanks

himam, India

my dear i have used venlift75mg in the year 2002. when i started venlift 75 within month i got effected with diarreria, anxiety, headache. but doctor forced me to continue for one year.side effects are uncontrollable then i stopped using venlift but till now i am facing side effects please help me

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