This medication is a topoisomerase type I inhibitor, prescribed for ovarian or lung cancer that do not respond well to other types of cancer treatment. It kills the cancer cells in ovary and lungs.
Contraindicated in pregnant and breastfeeding women, and hypersensitivity.
IV- The recommended dose is 1.5 mg/m2/day over 30 minutes, on 1 to 5 days. It is given in uterus and small cell lung cancer as an IV infusion in a dose of 1.5 mg/m2/day for the first 5 days of a 21-day course. The patient has to undergo at least 4 courses.
In cancer of the cervix a dose of 0.75 mg/m2 is given for 3 days along with cisplatin on the first day of a 21-day course.
This medication available in the form of capsule to take by mouth with a full glass (8 ounces) of water, with or without food. (Swallow whole, do not open/ chew/ crush.)
Injection: Intravenously (into a vein) over 30 minutes by healthcare providers.
• Caution needed for patients with history of pre existing bone marrow depression.
• Frequent monitoring of blood counts during treatment.
• It may cause dizziness, do not drive a car or operate machinery while taking this medication.
• Central Nervous System:
Fatigue, weakness, discomfort,headache.
• Blood: Abnormal low white blood cell count, hemoglobin.
• Miscellaneous: GI upset, total hair loss, shortness of breath, itching and increased levels of bilirubin.
Avoid alcoholic beverages while taking this medication.
Intravenous: Unopened vial: Store at 20-25°C; protect from light. Reconstituted solution: Stable for 24 hour at 20-25°C in ambient light.
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