Information about Topotecan

Generic Name : Topotecan
Up-to-date prescription details regarding Topotecan are provided here.

Pronunciation : toe'' poe tee' kan

Learn the correct pronunciation of the Topotecan, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.

You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

Trade Names/Brand Names of Topotecan

India :

Topotel | Cantop | Cantop (2.5mg) | Topotel (4 mg)

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International :

Hycamtin

Why is Topotecan Prescribed? (Indications)

This medication is a topoisomerase type I inhibitor, prescribed for ovarian or lung cancer that do not respond well to other types of cancer treatment. It kills the cancer cells in ovary and lungs.

When should Topotecan not be taken? (Contraindications)

Contraindicated in pregnant and breastfeeding women, and hypersensitivity.

What is the dosage of Topotecan?

IV- The recommended dose is 1.5 mg/m²/day over 30 minutes, on 1 to 5 days. It is given in uterus and small cell lung cancer as an IV infusion in a dose of 1.5 mg/m²/day for the first 5 days of a 21-day course. The patient has to undergo at least 4 courses.
In cancer of the cervix a dose of 0.75 mg/m² is given for 3 days along with cisplatin on the first day of a 21-day course.

How should Topotecan be taken?

This medication available in the form of capsule to take by mouth with a full glass (8 ounces) of water, with or without food. (Swallow whole, do not open/ chew/ crush.)
Injection: Intravenously (into a vein) over 30 minutes by healthcare providers.

What are the warnings and precautions for Topotecan?

•Caution needed for patients with history of pre existing bone marrow depression.

• Frequent monitoring of blood counts during treatment.

• It may cause dizziness, do not drive a car or operate machinery while taking this medication.

What are the side effects of Topotecan?

Central Nervous System- Fatigue, weakness, discomfort,headache.
Blood- Abnormal low white blood cell count, hemoglobin.
Miscellaneous- GI upset, total hair loss, shortness of breath, itching and increased levels of bilirubin.