Dr. Ramya Rachamanti
Medically Reviewed by The Medindia Medical Review Team on Nov 29, 2018
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General Information on Suvorexant

Generic Name : Suvorexant

Pronunciation : soo-voe-rex-ant.

Latest prescription information about Suvorexant. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Suvorexant


Overview of Suvorexant

Suvorexant is an orexin antagonist used for the treatment of insomnia (lack of sleep). Insomnia is when there is difficulty with the onset and sometimes also with the maintenance of sleep or when both occur.

Why is Suvorexant Prescribed? (Indications)

Suvorexant tablets are used in treating insomnia patients who are having difficulty with sleep onset and/or sleep maintenance 

When should Suvorexant not to be taken? (Contraindications)

Suvorexant should not be used in patients:

with an allergy to suvorexant
with narcolepsy
who are pregnant and breastfeeding women

What is the dosage of Suvorexant?

Suvorexant tablets are available in the doses of 5 mg, 10 mg, 15 mg, 20 mg to be taken by mouth at night time for treating Insomnia or sleeplessness.

How should Suvorexant be taken?

The initial recommended dose is 10 mg taken once every night within 30 minutes of going to bed, with at least 7 hours remaining before the intended time of waking up.
If the 10 mg dose is tolerated well, but not effective, the dose can be raised, but it should not exceed 20 mg once daily.
The effect may be delayed if taken with or soon after food.

What are the warnings and precautions for Suvorexant?

Suvorexant may cause daytime somnolence (excess sleepiness).

Risk of impaired alertness, motor coordination, impaired driving may be seen which increases with increase in the dose. So, patients are advised to take a low dose in case of next-day driving and other activities requiring full mental alertness.

Nighttime sleep-driving and other abnormal behaviors, sleep paralysis, hallucinations may be seen with excess dose and with use of CNS depressants, alcohol along with suvorexant. Family members should monitor these effects and should inform the health care provider during their next visit.

Worsening of depression or suicidal thoughts may occur. Evaluate the patient for any new behavioral changes and take to a nearby hospital immediately.

Patients are reevaluated if insomnia persists after 7 to 10 days of treatment.

What are the side effects of Suvorexant?

The most common side effect is somnolence (sleepiness)

What are the other precautions for Suvorexant?

Suvorexant is not recommended in patients with severe liver damage.
The patient should read the medication guide before taking this medicine.
Patients who are more sensitive to suvorexant taking lower doses should also be advised about the potential for driving impairment.
Patients are advised not to use suvorexant if they drank alcohol that evening or before bed.
Patients should not increase the dose of suvorexant on their own if they think that the medicine does not work.
Patients are advised to inform all of their prescription and nonprescription medicines, vitamins and herbal products to their doctor.

What are the Drug Interactions of Suvorexant?

Suvorexant dose should be reduced to 5 mg when used along with anti-viral medicines like amprenavir, atazanavir, antibiotics like ciprofloxacin, erythromycin, antifungal medicines like fluconazole, and others like imatinib, verapamil.
The dose should be reduced if the patient is consuming grapefruit juice regularly.
The dose can be increased to 10mg if 5mg is not producing sufficient effect.
Suvorexant is not recommended if patients are taking antifungal medicines like ketoconazole, itraconazole, antibiotics like clarithromycin, antiviral drugs like ritonavir, saquinavir, nelfinavir, telaprevir.
Digoxin blood levels should be monitored when prescribed along with digoxin.
Suvorexant effect may be decreased when used along with rifampin, carbamazepine, and phenytoin.

What are the storage conditions for Suvorexant?

Suvorexant tablets are stored at 20C to 25C
Tablets must be protected from light and moisture.

Last Updated : 11/29/2018

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