List of Drugs that may cause Somnolence (Drowsiness)

Acetaminophen and Codeine

Most Common - Drowsiness, lightheadedness, dizziness, slow heartbeat, sedation, shortness of breath, unusual thoughts or behavior, nausea, vomiting, flushing, vision changes, easy bruising or bleeding, stomach pain, loss of appetite, constipation, itching, decrease in platelets in blood, dark urine, clay-colored stools and difficulty in urinating

Agalsidase

Most Common - Chills, fever, feeling hot or cold, difficulty in breathing, nausea, swelling of the face, mouth, and throat, flushing, headache, vomiting, tingling, fatigue, itching, pain in extremity, high blood pressure, chest pain, throat tightness, abdominal pain, dizziness, fast heart rate, nasal congestion, diarrhea, muscle pain, back pain, pallor, slow heart rate, hives, low blood pressure, face swelling, rash, and drowsiness
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Almotriptan

Most Common- Nausea, drowsiness, headache, tingling and dry mouth

Apomorphine

Most Common- Yawning, involuntary movements, nausea, vomiting, bruising, redness at the injection site region, drowsiness, dizziness, runny nose, hallucinations, swelling, chest pain, increased sweating, flushing and pallor

Asenapine

Most Common - Brain disorder, movement disorder, weight increased and drowsiness

Azelastine

Most Common- Bitter taste, headache, drowsiness, nasal burning, inflammation of pharynx/nose, dry mouth, sneezing, nausea, fatigue, dizziness, nosebleed and increased weight

Bendamustine hydrochloride

Most Common - Fever, nausea and vomiting, weakness, fatigue, uneasiness, dry mouth, drowsiness, cough, constipation, headache and mouth ulcer

Biperiden

Most Common- Drowsiness, dizziness, headache, loss of appetite, blurred vision, agitation, postural hypotension, stomach upset, vision changes, sleeplessness, trembling of the hands and dry mouth

Brompheniramine

Most Common- Drowsiness, confusion, dizziness, dryness of mouth, nose, and throat, nausea, vomiting, abdominal cramps, headache and chest congestion

Cetirizine

Most Common - Headache, inflammation of pharynx, abdominal pain, cough, drowsiness, diarrhea, nosebleed, asthma, nausea and vomiting

Chlordiazepoxide

Most Common - Drowsiness, dizziness, tiredness, weakness, dry mouth, diarrhea, stomach upset and changes in appetite

Chlorpheniramine- Hydrocodone- Pseudoephedrine

Most Common - Sedation, drowsiness, mental clouding, lethargy, impairment of mental and physical performance, anxiety, fear, dizziness, psychic dependence, mood changes, nervousness, sleeplessness, visual disturbances, confusion, headache, emotion, involuntary repetitive movements of face, lightheadedness, agitation, restlessness, irritability, tremor

Chlorpromazine

Most Common - Jaundice, involuntary muscle movements, reduced white blood cell counts, low blood pressure and drowsiness

Clonidine

Most Common - Dry mouth, drowsiness, fatigue, headache, lethargy, sedation, sleeplessness, dizziness, impotence/sexual dysfunction, dry throat, constipation, tingling, nausea and vomiting

Cyclobenzaprine

Most Common - Drowsiness, headache, dizziness, blurred vision, nausea, abnormal taste, palpitations, tremor, dry throat, pimples, attention disturbances, sleeplessness, fatigue, constipation and indigestion

Desvenlafaxine

Most Common- Nausea, dizziness, sleeplessness, excessive sweating, constipation, drowsiness, decreased appetite, anxiety and specific male sexual function disorders

Dexmethylphenidate Hcl

Most Common- Nausea, dizziness, sleeplessness, excessive sweating, constipation, drowsiness, decreased appetite, anxiety and specific male sexual function disorders

Diazepam

Most Common - Drowsiness, fatigue and incoordination

Dichlorphenamide

Most Common- Loss of appetite, nausea, vomiting, drowsiness and tingling

Divalproex

Most Common- Nausea, vomiting, drowsiness, dizziness, weakness, abdominal pain, indigestion and rash

Doxylamine

Most Common- Dry mouth, nose and throat, drowsiness, nausea, difficulty in urinating

Enflurane

Most Common- High body temperature, hallucinations, abnormal heart rhythm, fainting or lightheadedness, dizziness and drowsiness

Etizolam

Most Common - Drowsiness, sedation, muscle weakness and incoordination

Felbamate

Most Common - Loss of appetite, vomiting, nausea, dizziness, drowsiness and headache

Fluoxetine and Olanzapine

Most Common - Disturbance in attention, dry mouth, fatigue, excessive sleepiness, increased appetite, swelling in the extremities, drowsiness, tremor, blurred vision , and increased weight

Flurazepam

Most Common - Dizziness, drowsiness, light-headedness, staggering, in-coordination and falling

Fluvoxamine

Most Common- Nausea, sleeplessness, drowsiness, headache, weakness, vomiting, nervousness, agitation and dizziness

Fomepizole

Most Common- Headache, nausea, dizziness, increased drowsiness and bad /metallic taste

Furosemide and Spironolactone

Most Common - Fluid and electrolyte imbalance, dehydration, nausea, diarrhea, blurred vision, headache, dizziness, drowsiness, low blood pressure, liver dysfunction, high blood sugar

Guanabenz

Most Common - Dry mouth, drowsiness, dizziness, weakness, headache, decreased sexual ability, stomach upset

Ketorolac

Most Common- Rash, ringing in the ears, headache, dizziness, drowsiness, abdominal pain, nausea, diarrhea, constipation, heartburn and fluid retention

Lamotrigine

Most Common- Adult: Rash, dizziness, headache, lack of coordination, nausea, vomiting, blurred vision, drowsiness, and nose inflammation

Lithium

Most Common - Diarrhea, vomiting, drowsiness, muscular weakness and lack of coordination

Loratadine

Most Common - Fatigue, giddiness, dizziness, dry mouth, headache, nausea and drowsiness

Lurasidone

Most Common - Drowsiness, unpleasant sensations, nausea, parkinsonism and agitation

Mephenesin

Most Common - Lassitude, drowsiness, weakness, loss of appetite, nausea and vomiting, hypersensitivity reactions

Meprobamate and Aspirin

Most Common - Drowsiness, heartburn or indigestion, nausea with or without vomiting and stomach pain (mild)

Methylphenidate

Most Common - Nervousness, difficulty in sleeping, skin rash, loss of appetite, dizziness, drowsiness, palpitations, fever, sore throat, unusual bleeding or bruising

Nabilone

Most Common- Dizziness, drowsiness, dry mouth, elevated mood, anxiety, lightheadedness, headache, trouble sleeping, memory problems, confusion and depression

Nefazodone

Most Common - Drowsiness, dry mouth, dizziness, constipation, weakness, lightheadedness, blurred vision, confusion and abnormal vision

Nefopam

Most Common- Drowsiness, lightheadedness, dry mouth, pink colored urine, nervousness, difficulty in urination, nausea, fainting, tremor and confusion

Nicorandil

Most Common- Headache, dizziness, drowsiness, nausea, vomiting, flushing, weakness and rectal bleeding

Orphenadrine

Most Common - Agitation, drowsiness, dizziness, emotion, hallucinations, headache and mental confusion

Oxcarbazepine

Most Common- Dizziness, drowsiness, double vision, running nose, fatigue, nausea, vomiting, ataxia, abnormal vision, sore throat, abdominal pain, tremor, indigestion, abnormal gait

Oxymorphone

Most Common- Nausea, constipation, dizziness, vomiting, itching, drowsiness, headache and increased sweat

Paliperidone Palmitrate

Most Common- Extra pyramidal symptoms, fast heart rate, inner restlessness, drowsiness, indigestion, constipation, weight increased, and inflammation of nasopharynx

Paroxetine

Most Common - Weakness, sweating, nausea, decreased appetite, drowsiness, dizziness, sleeplessness, tremor, nervousness, ejaculatory disturbance, and other male genital disorders

Perampanel

Most Common - Dizziness, drowsiness, headache, fatigue, irritability

Pethidine

Most Common- Nausea, vomiting, constipation, drowsiness, dizziness, dry mouth and sweating

Piribedil

Most Common - Nausea, vomiting, dizziness, confusion, drowsiness and movement disorder

Plicamycin

Most Common - Loss of appetite, nausea, vomiting, diarrhea, mouth ulcer, fever, drowsiness, weakness, lethargy, uneasiness, headache, depression, vein inflammation, facial flushing, and skin rash

Pralidoxime

Most Common - Blurred vision, double vision, impaired accommodation, dizziness, headache, drowsiness, nausea, muscle weakness, and fast heart rate

Pramipexole

Most Common - Nausea, dizziness, somnolence, insomnia, constipation, weakness and hallucinations

Prazosin

Most Common - Dizziness, headache, drowsiness, lack of energy, weakness, palpitations and nausea

Prochlorperazine

Most Common - Drowsiness, dizziness, absence of menstrual periods, blurred vision, skin reactions and Neuroleptic Malignant Syndrome (NMS)

Raxibacumab

Most Common- Rash, pain in extremity, itching and drowsiness

Ropinirole

Most Common - Involuntary movements, nausea, dizziness, hallucinations, drowsiness, abdominal pain/discomfort and low blood pressure

Sodium Oxybate

Most Common- Headache, nausea, dizziness, throat pain, drowsiness, vomiting, and urinary incontinence

Terazosin

Most Common - Drowsiness, headache, weakness, palpitations, stuffy nose, blurred vision and decreased sexual ability

Thalidomide

Most Common - Drowsiness, dizziness, constipation, confusion, difficulty in breathing and rash

Thiopental

Most Common- Respiratory depression, heart attack, irregular heart rate, drowsiness, sneezing, coughing, asthma and shivering

Tiagabine

Most Common- Dizziness, lightheadedness, weakness, drowsiness, nausea, nervousness, tremors, abdominal pain, abnormal or difficulty with thinking or concentration or attention

Tolcapone

Most Common- Movement disorder, nausea, sleep disorder, involuntary movements, excessive dreaming, loss of appetite, muscular cramps, orthostatic complaints, drowsiness, diarrhea, confusion, dizziness, headache, hallucinations, vomiting, constipation, fatigue, upper respiratory tract infection, falling, increased sweating, urinary tract infection, dry mouth, abdominal pain and urine discoloration

Tramadol

Most Common- Dizziness/vertigo, nausea, constipation, headache, drowsiness, vomiting, itching, CNS stimulation, weakness, sweating, indigestion, dry mouth and diarrhea

Triazolam

Most Common - Weakness, tiredness, dizziness, drowsiness, clumsiness, unsteadiness, "hangover" effect, headache, increased dream frequency, loss of memory, nausea and vomiting

Trifluoperazine

Most Common - Drowsiness, dizziness, skin reactions, rash, dry mouth, sleeplessness, absence of menstrual periods, fatigue, muscular weakness, loss of appetite, spontaneous secretion of milk, blurred vision and neuromuscular (extrapyramidal) reactions

Vigabatrin

Most Common- Headache, drowsiness, fatigue, dizziness, seizures, increased weight, upper respiratory tract infection, visual defects, depression, tremor, night blindness, nausea, diarrhea, memory loss, sleeplessness, irritability, abnormal coordination, blurred vision, double vision, vomiting, influenza, fever and rash

Ziprasidone

Most Common- Nausea, vomiting, drowsiness, runny nose, weakness

Zolmitriptan

Most Common- Pain or tightness in the chest or throat, tingling sensations, flushing, weakness, drowsiness, dizziness, abdominal discomfort and sweating

Zonisamide

Most Common- Drowsiness, loss of appetite, dizziness, unsteadiness, agitation/irritability, memory loss and poor concentration


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