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Siponimod - Indications, Dosage, Side Effects and Precautions

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General Information on Siponimod

Generic Name : Siponimod
Pronunciation : si-PON-i-mod
Latest prescription information about Siponimod. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, warnings and its storage instructions . Also listed are the Indian trade name(s) of the drug and its price list.
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Trade Names/Brand Names of Siponimod

Mayzent
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Overview of Siponimod

Siponimod is used for treating an immune disorder named Multiple Sclerosis (MS), especially for relapsing-remitting disease among adult patients.

Why is Siponimod Prescribed? (Indications)

Siponimod is used for treating an immune disorder named Multiple Sclerosis (MS), especially for relapsing-remitting disease among adult patients. 

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When should Siponimod not be taken? (Contraindications)

1. Hypersensitivity to Siponimod
2. Patients with a genetic abnormality (CYP2C93/3 genotype)
3. Patients with a hospitalization history for heart attack, stroke, heart failure in the last 6 months
4. Patients with heart block.

What is the dosage of Siponimod?

The recommended initial dose is 2 mg once daily.
The recommended maintenance dosage is 1 mg once daily. The dose should be increased gradually.
Since MS is an immune disorder, Siponimod should be taken over a long period of time under the instruction of the doctor and one should regularly visit the doctor to ensure safety of the medication.

How should Siponimod be taken?

Siponimod is to be taken orally. They are available as 0.25 mg and 2 mg tablets.

Missed a Dose?

In case of missing a dose after initial dose-titration, the drug should be taken as soon as you remember.

What are the side effects of Siponimod?

o General: Headache, Infections, Decreased immunity
o Eye: Macular swelling
o Heart: Low heart rate, conduction abnormalities
o Gastrointestinal: Liver injury (raised liver enzymes)
o Vascular: Increased blood pressure
o Respiratory: Decreased lung capacity.

What are the other precautions for Siponimod?

1. Siponimod may increase the chance of infections. So, obtain a complete blood count (CBC) before initiating treatment.
2. Eye evaluation is recommended before starting treatment as there is an increased chance of macular swelling
3. Siponimod may lower heart rate. So, get cardiologist consultation before concomitant use with other drugs that decrease heart rate.
4. Siponimod may cause a decline in lung function. So, assess pulmonary function before starting the drug.
5. Check liver enzymes before initiation of drug.
6. Monitor BP frequently during treatment.
7. Women of childbearing potential should use effective contraception during and for 10 days after stopping Siponimod.

What are the Drug Interactions of Siponimod?

Siponimod will interact with the following drugs:
Quinidine, Procainamide, Amiodarone, Sotalol
Propranolol
Fluconazole
Rifampin
Carbamazepine etc.

What are the storage conditions for Siponimod?

Unopened containers: Store in a refrigerator between 2C to 8C Opened container: Store at 20C to 25C.

Last Updated : 2/23/2021



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