Pazufloxacin is a fluoroquinolone broad spectrum antibiotic which is effective against a variety of microorganisms including drug-resistant strains.
Pazufloxacin is prescribed to treat urinary tract infections and respiratory tract infections such as lung abscess and pneumonia.
It is also recommended for several abdominal infections such as peritonitis, liver abscess, gallbladder infection and uterine infection in women called endometritis.
Also, it is used in the treatment of secondary infections following injuries, burns and post-operative wounds.
Pazufloxacin has a broad spectrum of action against various bacteria that include gram positive, gram negative, some drug resistant as well as anaerobic bacteria.
Pazufloxacin should not be used in patients with the following conditions:
History of allergy to the quinolone group of drugs
Severe kidney impairment
Prolonged QT interval an abnormality on ECG
Pregnant women, children and elderly
The dosage is calculated based on patients age, body weight and the response to the treatment.
The recommended adult dosage is 500mg injected intravenously twice a day.
The maximum duration of pazufloxacin treatment should not go beyond two weeks.
Pazufloxacin comes in intravenous infusion form in a 100ml bottle, which has to be administered over 30-60 minutes.
Dosage has to be reduced to 300 mg twice daily in patients suffering from moderate-to-severe kidney damage.
General: Prolongation of QT interval which could result in life-threatening arrhythmia, Clostridium difficile colitis, rashes and other allergic reactions
Gastrointestinal: Diarrhea, nausea, and vomiting
Musculoskeletal: Risk of tendon swelling and tendon rupture
Central nervous system: Headache, insomnia, restlessness, rarely seizures or psychosis
Administration of pazufloxacin (fluoroquinolone antibiotic group) to athletes should be avoided because of the possibility of tendon swelling and rupture, especially of the Achilles tendon.
Anti-diabetics: Pazufloxacin may increase the hypoglycemic (glucose-lowering) activity of antidiabetes drugs
NSAIDs: Pazufloxacin may increase the neuroexcitatory (stimulation of neurons) activity when administered along with non-steroidal anti-inflammatory drugs (NSAIDs)
Cimetidine may increase the blood level of pazufloxacin, while pazufloxacin may increase the blood levels of drugs like cyclosporine, theophylline and the anticoagulant drug warfarin.
Probenecid could also affect the levels of pazufloxacin
Store at room temperature.
Keep in a well-closed container.
Protect from light.
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