Vijayaganesh Kasinathan
Written & Compiled by Pharmacist Vijayaganesh Kasinathan, B.Pharm, M.Pharm
Dr. Simi Paknikar
Medically Reviewed by Dr. Simi Paknikar, MD
Last Updated on Oct 13, 2017
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General Information on Pazufloxacin

Generic Name : Pazufloxacin

Latest prescription information about Pazufloxacin. Learn its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Anti- Infectives

Overview of Pazufloxacin

• Pazufloxacin is a fluoroquinolone broad spectrum antibiotic which is effective against a variety of microorganisms including drug-resistant strains.

Why is Pazufloxacin Prescribed? (Indications)

Pazufloxacin is prescribed to treat urinary tract infections and respiratory tract infections such as lung abscess and pneumonia.
It is also recommended for several abdominal infections such as peritonitis, liver abscess, gallbladder infection and uterine infection in women called endometritis.
Also, it is used in the treatment of secondary infections following injuries, burns and post-operative wounds.
Pazufloxacin has a broad spectrum of action against various bacteria that include gram positive, gram negative, some drug resistant as well as anaerobic bacteria.

When should Pazufloxacin not to be taken? (Contraindications)

Pazufloxacin should not be used in patients with the following conditions:

• History of allergy to the quinolone group of drugs
• Severe kidney impairment
• Seizure disorders
• Prolonged QT interval – an abnormality on ECG
• Pregnant women, children and elderly

What is the dosage of Pazufloxacin?

• The dosage is calculated based on patient’s age, body weight and the response to the treatment.
• The recommended adult dosage is 500mg injected intravenously twice a day.
• The maximum duration of pazufloxacin treatment should not go beyond two weeks.

How should Pazufloxacin be taken?

• Pazufloxacin comes in intravenous infusion form in a 100ml bottle, which has to be administered over 30-60 minutes.

What are the warnings and precautions for Pazufloxacin?

• Dosage has to be reduced to 300 mg twice daily in patients suffering from moderate-to-severe kidney damage.

What are the side effects of Pazufloxacin?

•  General: Prolongation of QT interval which could result in life-threatening arrhythmia, Clostridium difficile colitis, rashes and other allergic reactions
•  Gastrointestinal: Diarrhea, nausea, and vomiting
Musculoskeletal: Risk of tendon swelling and tendon rupture
•  Central nervous system: Headache, insomnia, restlessness, rarely seizures or psychosis

What are the other precautions for Pazufloxacin?

• Administration of pazufloxacin (fluoroquinolone antibiotic group) to athletes should be avoided because of the possibility of tendon swelling and rupture, especially of the Achilles tendon.

What are the Drug Interactions of Pazufloxacin?

• Anti-diabetics: Pazufloxacin may increase the hypoglycemic (glucose-lowering) activity of antidiabetes drugs
• NSAIDs: Pazufloxacin may increase the neuroexcitatory (stimulation of neurons) activity when administered along with non-steroidal anti-inflammatory drugs (NSAIDs)
• Cimetidine may increase the blood level of pazufloxacin, while pazufloxacin may increase the blood levels of drugs like cyclosporine, theophylline and the anticoagulant drug warfarin.
• Probenecid could also affect the levels of pazufloxacin

What are the storage conditions for Pazufloxacin?

• Store at room temperature.
• Keep in a well-closed container.
• Protect from light.

Last Updated : 10/13/2017

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