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General Information on Pazopanib

Generic Name : Pazopanib

Pronunciation : paz-OH-pa-nib

Latest prescription information about Pazopanib. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Pazopanib

International- Votrient.

Why is Pazopanib Prescribed? (Indications)

This medication is a tyrosine kinase inhibitor, prescribed for renal cell carcinoma.  It slows or stops the spread of cancer cells.

When should Pazopanib not to be taken? (Contraindications)

Contraindicated in patients with severe liver problem, bleeding problem and hypersensitivity.

What is the dosage of Pazopanib?

The recommended dose is 800 mg orally once daily without food. Maximum: 800 mg.

How should Pazopanib be taken?

It comes as a tablet and capsule to take by mouth, without food.

What are the warnings and precautions for Pazopanib?

Caution should be exercised in patients with history of liver problems, high blood pressure, irregular heartbeat, other heart problems, abnormal electrolyte levels, underactive thyroid, stomach problem, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.

Avoid contact with people who have infections that may spread to others.

Patient may develop with increased risk of bleeding disorder with the following conditions: blood in the urine, coughing or spitting up blood, severe or persistent nosebleed. If it is so consult with your doctor.

Monitor liver and thyroid function, urine protein levels, blood pressure, blood electrolytes, and heart function regularly while taking this medication.

What are the side effects of Pazopanib?

   Most Common : Diarrhea, high blood pressure, hair color change, nausea, fatigue, loss of appetite and vomiting.
   Heart : Heart attack, QT prolongation, stroke and torsade de pointes (fast heart rate).
   Central Nervous System : Weakness and headache.
   Skin : Hair loss and rash.
   Eye and ENT : Nosebleed.
   Gastrointestinal : Abdominal pain, indigestion, rectal bleeding and decrease in taste sensitivity.
   Genitourinary : Protein and blood in urine.
   Blood : Decrease in white blood cells and platelets.
   Metabolic : Underactive thyroid, increase in liver enzyme and decrease in blood minerals.
   Respiratory : Bloodstained sputum.
   Miscellaneous : Bleeding disorder, decreased weight hand-foot syndrome with reddening, swelling, numbness and desquamation, swelling in the face and fistula.

What are the other precautions for Pazopanib?

Avoid excess dosage.

What are the storage conditions for Pazopanib?

Store it at room temperature (25C), and in an airtight container.

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