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General Information on Olanzapine and Fluoxetine

Generic Name : Olanzapine and Fluoxetine

Pronunciation : oh-LAN-za-peen- floo-OX-e-teen

Latest prescription information about Olanzapine and Fluoxetine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y49.5 | Therapeutic Classification : Antipsychotics

Trade Names/Brand Names of Olanzapine and Fluoxetine

International- Symbyax.

Why is Olanzapine and Fluoxetine Prescribed? (Indications)

This medication is a combination of an atypical antipsychotic and a selective serotonin reuptake inhibitor (SSRI), prescribed for depression in patients with bipolar disorder. 

When should Olanzapine and Fluoxetine not to be taken? (Contraindications)

It should not be co-administered with monoamine oxidase inhibitors (MAOI), pimozide, thioridazine.

What is the dosage of Olanzapine and Fluoxetine?

Adult- PO- The recommended initial dose is 6mg/25mg (1capsule). Maximum: 12mg/50mg.

How should Olanzapine and Fluoxetine be taken?

It comes as a capsule to take by mouth, on an empty stomach or with food.

What are the warnings and precautions for Olanzapine and Fluoxetine?

Caution should be exercised in patients with history of seizures, heart problems, abnormal electrocardiogram (ECG), heart attack, stroke, high blood cholesterol, high or low blood pressure, decrease in white blood cells, liver or kidney disease, stomach problem, bleeding disorder, enlarged prostate, increased eye pressure, neuroleptic malignant syndrome (NMS), prolonged painful erection, poor metabolism, dehydration, Alzheimer disease, dementia, diabetes, mental illness, who are taking other medications, any allergy, elderly, children, during pregnancy and breastfeeding.

It may cause drowsiness, dizziness, or blurred vision, do not drive a car or operate machinery and get up slowly from bed while taking this medication.

Avoid alcohol consumption while taking this medication.

Avoid becoming overheated or dehydrated in hot weather; otherwise heatstroke may occur.

Avoid contact with people with infections that may spread to others.

Patient may develop with increased risk of Serotonin Syndrome with the following symptoms: agitation, confusion, hallucinations, coma, fever, irregular heartbeat, tremor, excessive sweating, nausea, vomiting, and diarrhea.

What are the side effects of Olanzapine and Fluoxetine?

   Eye and ENT : Vision blurred.
   Gastrointestinal : Dry mouth, flatulence, and abdominal distension.
   General : Fatigue, fluid retention, swelling in the extremities, weakness, pain, fever.
   Infections : Sinusitis.
   Metabolic : Increased weight and appetite.
   Musculoskeletal : Joint pain, pain in extremity, stiffness.
   Central Nervous system : Drowsiness, tremor, sedation, sleepiness, disturbance in attention, laziness, restlessness, abnormal thinking, nervousness.
   Genitourinary : Impotence.

What are the other precautions for Olanzapine and Fluoxetine?

Avoid excess dosage.

What are the storage conditions for Olanzapine and Fluoxetine?

Store at 25C and in an airtight container.

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