- Efficacy and safety of nebivolol in elderly heart failure patients with impaired renal function: insights from the SENIORS trial - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729679/ )
- Effect of treatment with nebivolol on parameters of oxidative stress in type 2 diabetics with mild to moderate hypertension - ( https://pubmed.ncbi.nlm.nih.gov/16635049/ )
- Nebivolol - (https://medlineplus.gov/druginfo/meds/a608029.html )
- Impact of beta-blockers on sleep in patients with mild hypertension: a randomized trial between nebivolol and metoprolol - ( https://pubmed.ncbi.nlm.nih.gov/18758699/ )
- Influence of chronic kidney disease and haemodialysis treatment on pharmacokinetics of nebivolol enantiomers - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917815/ )
Nebivolol Medication Information
Get detailed information on Nebivolol, including pronunciation, uses, dosage guidelines, indications, and instructions on how and when to take it and when to avoid it.
The updated prescription information on Nebivolol provides an overview of possible side effects, precautions, warnings, and storage tips.
You'll also find brand names used in india and internationally, along with pricing details. For further clarification, consult your healthcare provider.
Generic Name : Nebivolol Pronunciation : ne-BIV-oh-lol ICD Code : Y51.7 Therapeutic Classification : Anti- HypertensivesTrade Names/Brand Names of Nebivolol
India :
Zinebi (5mg) |
Nebilol (2.5 mg) |
Cardilol - AM |
Betalol (5 mg) |
Zenebi |
Nebula |
Nebest (5mg) |
Amlovas -SN |
Nebicard SM |
Nebilong
International :
Bystolic
Why is Nebivolol Prescribed? (Indications)
Nebivolol is a beta-blocker, prescribed for hypertension either alone or combined with other medications. It is also used for some cases of heart failure. It decreases the amount of blood pumped out from heart. This helps to decrease blood pressure and reduces the workload on the heart.When should Nebivolol not be taken? (Contraindications)
Nebivolol should not be used in patients allergic to the drug, with slow heartbeat, low cardiac output, or liver failureWhat is the dosage of Nebivolol?
Hypertension- 5 to 40mg once daily.Heart failure: 1.25-10 mg once daily.
How should Nebivolol be taken?
It comes as a tablet to take by mouth, with or without food once a day.What are the warnings and precautions for Nebivolol?
•Avoid abrupt withdrawal of the drug.The drug should be used with caution if the patient is having any of these conditions:
• Occasional numbness and tingling in the fingers.• Asthma.
• Chronic obstructive pulmonary disease (COPD).
• Diabetes, since it may mask the effects of low blood sugar levels.
• Hyperthyroidism, or high thyroid hormone levels.
• Kidney or liver function problems. These patients are started with a low dose.
• Skin condition called psoriasis.
• Untreated pheochromocytoma, which is a tumor of the adrenal gland.
• Metabolic acidosis like diabetic ketoacidosis.
What are the side effects of Nebivolol?
Heart- Slow heart rate, heart failure, low blood pressure .Gastrointestinal- Diarrhea, nausea, abdominal pain,constipation.
Central Nervous System- Headache, dizziness, sleeplessness, weakness, tingling.
Respiratory- Wheezing, cough, nasopharyngitis (inflammation of nose and throat).
Skin- Rash.
Metabolic- Increased level of cholesterol, and uric acid in the blood.
Others: fatigue, peripheral edema, joint pain, rash
What are the other precautions for Nebivolol?
Avoid excess dosage.Nebivolol may cause dizziness, do not drive a car or operate machinery while taking this medication.
What are the Drug Interactions of Nebivolol?
Nebivolol should be avoided with:• Other beta blockers due to additive effects.
• Other drugs with depressant effects on the heart including calcium channel blockers like amlodipine, verapamil and diltiazem, heart failure drugs digoxin or digitoxin, and drugs that normalize heart rhythm like quinidine, disopyramide, flecainide, and mexiletine. Combination with some of these drugs may be necessary in cases that cannot be controlled with a single drug.
• Antidiabetic drugs since nebivolol can block the signs and of low blood sugar levels.
• Drugs that inhibit CYP2D6 enzyme like paroxetine, fluoxetine and thioridazine, which can increase nebivolol level in the blood resulting in reduced heart rate.
• Drugs used in the treatment of asthma due to opposite effects on the bronchi.
• Non-steroidal anti-inflammatory drugs like ibuprofen and diclofenac which may block the action of nebivolol on blood pressure.
• Other drugs which reduce blood pressure due to additive effect.
• Antipsychotics like phenothiazines, barbiturates and tricyclic antidepressants due to excessive reduction in heart rate.
