- Efficacy and safety of nebivolol in elderly heart failure patients with impaired renal function: insights from the SENIORS trial - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729679/ )
- Effect of treatment with nebivolol on parameters of oxidative stress in type 2 diabetics with mild to moderate hypertension - ( https://pubmed.ncbi.nlm.nih.gov/16635049/ )
- Nebivolol - (https://medlineplus.gov/druginfo/meds/a608029.html )
- Impact of beta-blockers on sleep in patients with mild hypertension: a randomized trial between nebivolol and metoprolol - ( https://pubmed.ncbi.nlm.nih.gov/18758699/ )
- Influence of chronic kidney disease and haemodialysis treatment on pharmacokinetics of nebivolol enantiomers - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917815/ )
Information about NebivololGeneric Name : Nebivolol
Up-to-date prescription details regarding Nebivolol are provided here.
Pronunciation : ne-BIV-oh-lol
Learn the correct pronunciation of the Nebivolol, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.
ICD Code : Y51.7 Therapeutic Classification : Anti- Hypertensives
Trade Names/Brand Names of Nebivolol
Why is Nebivolol Prescribed? (Indications)Nebivolol is a beta-blocker, prescribed for hypertension either alone or combined with other medications. It is also used for some cases of heart failure. It decreases the amount of blood pumped out from heart. This helps to decrease blood pressure and reduces the workload on the heart.
When should Nebivolol not be taken? (Contraindications)Nebivolol should not be used in patients allergic to the drug, with slow heartbeat, low cardiac output, or liver failure
What is the dosage of Nebivolol?Hypertension- 5 to 40mg once daily.
Heart failure: 1.25-10 mg once daily.
How should Nebivolol be taken?It comes as a tablet to take by mouth, with or without food once a day.
What are the side effects of Nebivolol?Heart- Slow heart rate, heart failure, low blood pressure .
Gastrointestinal- Diarrhea, nausea, abdominal pain,constipation.
Central Nervous System- Headache, dizziness, sleeplessness, weakness, tingling.
Respiratory- Wheezing, cough, nasopharyngitis (inflammation of nose and throat).
Metabolic- Increased level of cholesterol, and uric acid in the blood.
Others: fatigue, peripheral edema, joint pain, rash
What are the other precautions for Nebivolol?Avoid excess dosage.
Nebivolol may cause dizziness, do not drive a car or operate machinery while taking this medication.
What are the Drug Interactions of Nebivolol?Nebivolol should be avoided with:
• Other beta blockers due to additive effects.
• Other drugs with depressant effects on the heart including calcium channel blockers like amlodipine, verapamil and diltiazem, heart failure drugs digoxin or digitoxin, and drugs that normalize heart rhythm like quinidine, disopyramide, flecainide, and mexiletine. Combination with some of these drugs may be necessary in cases that cannot be controlled with a single drug.
• Antidiabetic drugs since nebivolol can block the signs and of low blood sugar levels.
• Drugs that inhibit CYP2D6 enzyme like paroxetine, fluoxetine and thioridazine, which can increase nebivolol level in the blood resulting in reduced heart rate.
• Drugs used in the treatment of asthma due to opposite effects on the bronchi.
• Non-steroidal anti-inflammatory drugs like ibuprofen and diclofenac which may block the action of nebivolol on blood pressure.
• Other drugs which reduce blood pressure due to additive effect.
• Antipsychotics like phenothiazines, barbiturates and tricyclic antidepressants due to excessive reduction in heart rate.