Information about Lepirudin

Generic Name : Lepirudin
Up-to-date prescription details regarding Lepirudin are provided here.

Pronunciation : le-PEER-u-din

Learn the correct pronunciation of the Lepirudin, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.

You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

ICD Code : Y44.2 Therapeutic Classification : Anticoagulants / Antithrombotics

Trade Names/Brand Names of Lepirudin

International :

Refludan

Why is Lepirudin Prescribed? (Indications)

This medication is an anticoagulant, prescribed for heparin-induced thrombocytopenia (HIT). It blocks thrombin activity that helps to prevent the formation of blood clots.

When should Lepirudin not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Lepirudin?

Adult: IV- 0.4 mg/kg body weight (up to 110kg) slowly intravenously (eg, over 15 to 20seconds) as a bolus dose.
Followed by 0.15 mg/kg body weight (up to 110kg)/hour as a continuous intravenous infusion for 2 to 10 days or longer if clinically needed.

How should Lepirudin be taken?

It comes as a solution for injection, to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Lepirudin?

• Caution should be exercised in patients with history of heart infection, high blood pressure, stomach ulcers, liver or kidney problems, head injury, stroke, any allergy, bleeding problems, stomach/intestinal problems, elderly, children, during pregnancy and breastfeeding.

• Monitor blood counts, blood pressure while taking this medication.

What are the side effects of Lepirudin?

Heart- Heart failure.
Skin- Bleeding in injection site, wounds and allergic skin reactions.
Eye and ENT- Nosebleed.
Gastrointestinal- Gastrointestinal and rectal bleeding.
Genitourinary- Abnormal kidney function, blood in urine and vaginal bleeding.
Blood- Anemia and sepsis.
Liver- Abnormal liver function.
Respiratory- Pneumonia.
Miscellaneous- Fever and infection.