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General Information on Imipenem and Cilastatin

Generic Name : Imipenem and Cilastatin

Pronunciation : Ih-mih-PEN-em- SIGH-lah-STAT-in

Latest prescription information about Imipenem and Cilastatin. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y41.8 | Therapeutic Classification : Anti- Infectives

Trade Names/Brand Names of Imipenem and Cilastatin

Why is Imipenem and Cilastatin Prescribed? (Indications)

This medication is a broad spectrum beta-lactam antibiotic, prescribed for severe body infections. Cilastatin helps Imipenem work more effectively.

When should Imipenem and Cilastatin not to be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Imipenem and Cilastatin?

Adult: IV- Susceptible infections- As imipenem: 1-2 g/day in divided doses 6-8 hourly.
Surgical prophylaxis- As imipenem: 1 g on induction of anesth, followed by 1 g 3 hours later. Additional doses of 500 mg may be given at 8 and 16 hr after induction if needed.
IM- Susceptible infections- As imipenem: 500 or 750 mg 12 hourly.
Uncomplicated gonorrhoea- As imipenem: 500 mg as single dose.

How should Imipenem and Cilastatin be taken?

It comes as a solution for injection to be administered by a healthcare provider either into the vein or into the large muscle.

What are the warnings and precautions for Imipenem and Cilastatin?

Caution should be exercised in patients with history of seizures, brain injury, kidney, liver or gastrointestinal disease (especially colitis), asthma, who are taking other medications, any allergy, elderly, children, during pregnancy and breastfeeding.

While taking this medication monitor blood sugar level in diabetic patients.

It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.

What are the side effects of Imipenem and Cilastatin?

  Skin : Rash and hives.
  Gastrointestinal: Nausea, vomiting, diarrhea, tooth or tongue discoloration and altered taste.
  Local: Inflammation, pain, vein inflammation and severe allergic reactions.

What are the other precautions for Imipenem and Cilastatin?

Avoid excess dosage.
Avoid prolonged or long-term use of this medication.
Monitor kidney function, liver function and complete blood cell count while taking this medication.

What are the storage conditions for Imipenem and Cilastatin?

Normally handled and stored by healthcare provider.

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