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Glipizide - Indications, Dosage, Side Effects and Precautions

Last Updated on August 11, 2022
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Information about Glipizide

Generic Name : Glipizide
Up-to-date prescription details regarding Glipizide are provided here.
Pronunciation : GLIP-i-zide
Learn the correct pronunciation of the Glipizide, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.
ICD Code : Y42.3 | Therapeutic Classification : Antidiabetics

Trade Names/Brand Names of Glipizide

India : 


International : 


Why is Glipizide Prescribed? (Indications)

This medication is a sulfonylurea antidiabetic agent, prescribed for type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood), particularly in people whose diabetes cannot be controlled by diet alone. It increases the amount of insulin secretion and thus regulates the sugar level in the blood. 

When should Glipizide not be taken? (Contraindications)

Contraindicated in patients with hypersensitivity, Type 1 diabetes, ketoacidosis, severe kidney or liver impairment, pregnancy and breastfeeding.

What is the dosage of Glipizide?

PO: Initial-2.5 to 5 mg/day as a single dose may increase slowly. Doses greater than 15 mg may be given in 2 divided doses. Max: 40 mg/day.

How should Glipizide be taken?

Extended-release: Should be taken with food. (Swallow whole, do not chew/ crush/ divide.)
Immediate-release: Should be taken on an empty stomach. (Take hour before meals.)

What are the warnings and precautions for Glipizide?

• Caution should be exercised in patients with history of liver, blood disorder.

Do not drink alcohol while you are taking this medication. It may increase the risk of low blood sugar.

It may increase the risk of death from heart disease, thyroid problem, moderate liver or kidney failure.

Monitor blood glucose concentration.

What are the side effects of Glipizide?

  Metabolic: Low blood sugar.
  Heart: Increased risk of death due to heart problems.
  Central Nervous System: Dizziness and vertigo.
  Skin: Allergic skin reactions, inflammation of skin, itching, redness, hives, eruptions and photosensitivity.
  Eye and ENT: Tinnitus.
  Gastrointestinal: GI disturbances (eg, nausea, loss of appetite, heartburn) and diarrhea.
  Genitourinary: Mild urinary frequency, elevated Blood, Urea, Nitrogen and creatinine levels.
  Liver: Jaundice and elevated LFT (liver function test) results.
  Blood: Decrease in white blood cells, platelets, hemoglobin.
  Miscellaneous: Disulfiram like reaction (symptoms like uneasiness, vomiting, mental confusion, chest pain, headache etc on taking alcohol while on the medication), weakness, tingling, fatigue and uneasiness.

What are the other precautions for Glipizide?

Proper diet, regular exercise needed. Do not change the dose of your medicine without checking with your doctor.

What are the storage conditions for Glipizide?

Store it at room temperature and away from excess heat and moisture. Keep in an airtight container and keep away from children.
Last Updated : August 11, 2022
Learn more about Glipizide's interaction with Alcohol

Glipizide : Frequently Asked Questions

Q: What happens if alcohol is taken with Glipizide?

A: Avoid alcohol intake while using glipizide as it can cause some side effects like low blood sugar level, nausea, vomiting, headache, rapid heartbeat, weakness and sudden changes in blood pressure(1 Trusted Source
Mixing Alcohol With Medicines

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Q: Is Glipizide better taken in the morning or at night?

A: Glipizide is available as immediate-release tablets and extended-release tablets for oral administration. Immediate-release tablet is usually taken once or twice a day, 30 minutes before breakfast or meals. The extended-release tablet is usually taken with breakfast once a day(2 Trusted Source

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Q: Is Glipizide safe in elderly patients?

A: Glipizide should be started at a lower dose in the elderly, malnourished patients, severely ill patients, and those with impaired liver, adrenal, or renal function, as higher doses can cause hypoglycemic episodes(3 Trusted Source

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Q: Who should not take Glipizide?

A: Glipizide is not recommended for patients who have hypersensitivity to sulfa drugs and patients with type 1 diabetes mellitus, diabetic ketoacidosis, and hyperosmolar hyperglycaemic state (HHS)(3 Trusted Source

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Q: Does Glipizide cause weight gain?

A: Yes, Glipizide can cause weight gain. Regular exercise and a healthy diet help with weight management(3 Trusted Source

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  • 1. Mixing Alcohol With Medicines - (https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/harmful-interactions-mixing-alcohol-with-medicines )
  • 2. Glipizide - (https://medlineplus.gov/druginfo/meds/a684060.html )
  • 3. Glipizide - (https://www.ncbi.nlm.nih.gov/books/NBK459177/ )
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edwardhoward, India

Glipizide is an oral medication used to lower blood glucose levels in type 2 diabetes [non-insulin-dependent diabetes] patients. It belongs to a class of drugs called sulfonylureas, which work by stimulating the pancreas to produce more insulin.

KMShah, India

How to overcome side effects? i.e. loss of appetite/weight loss etc

Doosriradha, India

JAYA JAYA SHRI KRUSHNA! I just chanced upon this medicine Glipizide for Diabetes Type-2. The information you have given here are complete and very helpful. I wonder why I was prescribed Gemer1. That is Metformin. Now, I want to know if Glipizide would be a better medicine for me.

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