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General Information on Febuxostat

Generic Name : Febuxostat

Pronunciation : feb ux' oh stat

Latest prescription information about Febuxostat. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y54.8 | Therapeutic Classification : Anti- Gout Medications

Overview of Febuxostat

The US FDA created an alert about the use of Febuxostat in Nov 2017. Febuxostat was approved in 2009 for treating gouty arthritis in adults but required the manufacturer to conduct a safety study as the drug label already carries a warning and precaution related to cardiovascular deaths.
The clinical trial was conducted in 6000 patients with gout treated with febuxostat compared to allopurinol. Febuxostat showed an increased risk of heart attacks, stroke, and heart-related deaths.
Healthcare professionals should always consider this FDA alert for safety reasons whether febuxostat needed to be prescribed. It is also advised that patients also should discuss with the physician or pharmacist in case they have any queries about the safety of febuxostat.
FDA is evaluating the safety of Febuxostat on a continuous basis and will update the public with necessary information. However, healthcare professionals and patients are requested to report for any side effects of febuxostat to the FDA MedWatch program.

Why is Febuxostat Prescribed? (Indications)

This medication is a xanthine oxidase (XO) inhibitor, prescribed for gout and hyperuricemia (high level of uric acid in blood). It decreases the amount of uric acid in blood. 

When should Febuxostat not to be taken? (Contraindications)

Contraindicated in patients treated with azathioprine, mercaptopurine or theophylline.

What is the dosage of Febuxostat?

PO- The recommended dose is 40 to 80mg, once daily.

How should Febuxostat be taken?

It comes as a tablet to take by mouth with or without food.

What are the warnings and precautions for Febuxostat?

• Caution should be exercised in patients with history of liver, kidney diseases, chest pain, cancer, stroke, elderly, children, pregnancy, and breastfeeding.

• Caution should be exercised in patients who have undergone organ transplantation (kidney, liver, heart and lung).

• If condition worsens, stop the medication immediately.

What are the side effects of Febuxostat?

•  Most Common: Swelling in the face, lips, tongue or throat regions, sweating, general illness and loss of appetite.
•  Skin: Allergic reactions.
•  Respiratory : Difficulty in breathing.
•  Heart: Chest pain and heaviness in the chest region.
•  Gastrointestinal : Nausea and stomach pain.
•  Central Nervous System: Headache and confusion.
•  Eye: Vision problems.
•  Genitourinary: Dark colored urine.
•  Less Common: Anemia, pain, swelling in the joint regions, stroke and inflammation of liver.
•  Liver: Liver failure and jaundice.

What are the other precautions for Febuxostat?

Patient may develop with severe blood clot events; if so contact your healthcare provider immediately.

What are the storage conditions for Febuxostat?

Store it at room temperature.

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edwardhoward, India

Uloric* [Febuxostat] is used to treat gout caused by excessive uric acid levels in the blood (hyperuricemia). It belongs to a class of medications called xanthine oxidase inhibitors. Generic for Uloric* works by decreasing the production of uric acid in the body.

jodywood, India

I have had the gout since I was 26, am now 73. I took Febuxostat 300mg which I bought here www.internationaldrugmart.com/febuxostat.shtml. [it worked]I have had no side effects, my blood tests are well in range. I am very pleased with this.

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