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Doxylamine Succinate and Pyridoxine Hydrochloride - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Doxylamine Succinate and Pyridoxine Hydrochloride

Generic Name : Doxylamine Succinate and Pyridoxine Hydrochloride
Pronunciation : dox-IL-a-meen PIR-i-DOX-een
Latest prescription information about Doxylamine Succinate and Pyridoxine Hydrochloride. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.0 | Therapeutic Classification : Antiemetics
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Trade Names/Brand Names of Doxylamine Succinate and Pyridoxine Hydrochloride

International- Diclegis, Debendox, Lenotan, Merbental, Diclectin.
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Why is Doxylamine Succinate and Pyridoxine Hydrochloride Prescribed? (Indications)

This combination medication is used to treat nausea and vomiting or morning sickness in pregnant women who do not respond to conservative management. 

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When should Doxylamine Succinate and Pyridoxine Hydrochloride not be taken? (Contraindications)

Contraindicated in patients with known hypersensitivity, asthma, increased intraocular pressure, narrow angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, urinary bladder-neck obstruction and women who are taking monoamine oxidase inhibitors (MAOIs).

What is the dosage of Doxylamine Succinate and Pyridoxine Hydrochloride?

Initially, take two DICLEGIS delayed-release tablets orally at bedtime (Day 1). If this dose adequately controls symptoms the next day, continue taking two tablets daily at bedtime. However, if symptoms persist into the afternoon of Day 2, take the usual dose of two tablets at bedtime that night then take three tablets starting on Day 3 (one tablet in the morning and two tablets at bedtime). If these three tablets adequately control symptoms on Day 4, continue taking three tablets daily. Otherwise take four tablets starting on Day 4 (one tablet in the morning, one tablet mid-afternoon and two tablets at bedtime).
The maximum recommended dose is four tablets (one in the morning, one in the mid-afternoon and two at bedtime) daily.

How should Doxylamine Succinate and Pyridoxine Hydrochloride be taken?

It comes as a tablet to take by mouth on an empty stomach.

What are the warnings and precautions for Doxylamine Succinate and Pyridoxine Hydrochloride?

• Do not engage in activities requiring complete mental alertness such as driving or operating heavy machinery, while using this medication.

Do not use this medication if you are concurrently using central nervous system (CNS) depressants including alcohol.

Do not crush, chew, or split tablets, swallow tablets whole.

Take this medication as a daily prescription and not on an as needed basis.

What are the side effects of Doxylamine Succinate and Pyridoxine Hydrochloride?

  General - Drowsiness, uneasiness, chest discomfort, irritability, fatigue.
  Respiratory - Shortness of breath, fast heart rate, abnormal heart beat.
  Gastrointestinal - Abdominal pain, constipation, diarrhea, abdominal distention.
  Genitourinary - Pain during urination, urinary retention.
  Central Nervous System - Dizziness, headache, abnormal sensation such as numbness, tingling, or burning, hyperactivity.
  Psychiatric - Anxiety, insomnia, nightmares, disorientation.
  Skin - Rash, excessive sweating, itching and irritation.
  Eye - Blurred vision, visual disturbances.

What are the other precautions for Doxylamine Succinate and Pyridoxine Hydrochloride?

Avoid excess dosage.

What are the storage conditions for Doxylamine Succinate and Pyridoxine Hydrochloride?

Store between 68F to 77F (20C to 25C) in a tightly closed container away from moisture, and light. Do not remove desiccant canister from bottle.


Schedule : G
Drugs that are to be used only under medical supervision.



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