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Diphenoxylate and Atropine - Indications, Dosage, Side Effects and Precautions

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Information about Diphenoxylate and Atropine

Generic Name : Diphenoxylate and Atropine
Up-to-date prescription details regarding Diphenoxylate and Atropine are provided here.

Pronunciation : AT-row-peen- dye-fen-OX-i-late

Learn the correct pronunciation of the Diphenoxylate and Atropine, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.


ICD Code : Y53.6 Therapeutic Classification : Antidiarrheals

Trade Names/Brand Names of Diphenoxylate and Atropine

International :


Lomotil, Lonox

Why is Diphenoxylate and Atropine Prescribed? (Indications)

This combination medication contains antidiarrheal (a narcotic) and anticholinergic agent, prescribed for diarrhea. Like other narcotics diphenoxylate doesn't have pain- relieving (analgesic) actions,but it reduces bowel activity.

When should Diphenoxylate and Atropine not be taken? (Contraindications)

Contraindicated in patients with jaundice, diarrhea associated with pseudomembranous enterocolitis, and hypersensitivity.

What is the dosage of Diphenoxylate and Atropine?

Adults: The recommended initial dosage is two tablets four times daily or 10 ml liquid four times daily (20 mg per day).

How should Diphenoxylate and Atropine be taken?

It comes as a tablet and liquid to take by mouth, with or without food.

What are the warnings and precautions for Diphenoxylate and Atropine?

• Caution should be exercised in patients with history of electrolyte imbalance, ulcerative colitis, liver or kidney impairment, Down syndrome, numbness, enlarged prostate, urinary obstruction, trouble in urinating, heart diseases, hiatal hernia, asthma, increased eye pressure, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.

• It may cause drowsiness, dizziness, or blurred vision, do not drive a car or operate machinery while taking this medication.

• Avoid alcohol consumption.

• Do not become overheated in hot weather; otherwise it may lead to heatstroke.

What are the side effects of Diphenoxylate and Atropine?

Central Nervous system - Numbness of extremities, emotion, depression, uneasiness, confusion, sedation, drowsiness, dizziness, restlessness, and headache.
Allergic Reactions - Anaphylaxis, fluid retention, hives, swelling of the gums, itching.
Gastrointestinal - Toxic megacolon, paralytic ileus, inflammation of pancreas, vomiting, nausea, and loss of appetite, abdominal discomfort.

What are the other precautions for Diphenoxylate and Atropine?

Avoid excess dosage.

What are the storage conditions for Diphenoxylate and Atropine?

Store the medication as directed by your physician.

Schedule : H
Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.
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