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Diphenhydramine - Indications, Dosage, Side Effects and Precautions

Last Updated on May 11, 2020
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Information about Diphenhydramine

Generic Name : Diphenhydramine
Pronunciation : dye fen hye' dra meen
Latest prescription information about Diphenhydramine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y55.5 | Therapeutic Classification : Antihistamines And Decongestants

Trade Names/Brand Names of Diphenhydramine

India : 


International : 

Aler-Dryl, Allergia-C, Allermax, Altaryl, Banophen, Benadryl, Bromanate, AF Bydramine, Compoz, Nighttime Sleep Aid, Dicopanol, Diphedryl, Diphen, Diphenadryl, Diphenhist, Diphenylin, Dytan, Hydrami Read more..

Why is Diphenhydramine Prescribed? (Indications)

This medication is an antihistamine, prescribed for severe allergic conditions such as runny nose, sneezing, itchy, watery eyes. It is also used for itching of insect bites, sunburns, bee stings, poison ivy, poison oak and minor skin irritation.  

When should Diphenhydramine not be taken? (Contraindications)

Contraindicated in newborns and patients with hypersensitivity.

What is the dosage of Diphenhydramine?

PO- Adult- The recommended dose is 25 mg to 50 mg (1 to 2 capsules).
Child- The recommended dose is 12.5 mg to 25 mg (1 capsule).
Topical: Apply a thin layer over the affected area as directed by your physician.

How should Diphenhydramine be taken?

It comes as a tablet to take by mouth, with or without food.
It also comes as a cream, lotion and ointment to apply topically.

What are the warnings and precautions for Diphenhydramine?

• Caution should be exercised in patients with history of asthma, lung disease, increased eye pressure, ulcer, difficulty in urinating, enlarged prostate, heart disease, high blood pressure, seizures, overactive thyroid, any allergy, who are taking other medications, during pregnancy and breastfeeding.

• It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.

• Avoid alcohol consumption.


• Avoid contact with eyes and mouth.

• Avoid using in patients with chickenpox, measles.

What are the side effects of Diphenhydramine?

   Topical : Skin rash, sunburn, increased sensitivity to sunlamps and sunlight.
   Miscellaneous : Drowsiness, dizziness, nausea, vomiting, constipation, headache, muscle weakness and nervousness.

What are the other precautions for Diphenhydramine?

Avoid excess dosage.

What are the storage conditions for Diphenhydramine?

Store it at room temperature.

Schedule : G
Drugs that are to be used only under medical supervision.
Last Updated : 3/5/2023
Learn more about Diphenhydramine's interaction with Alcohol

Diphenhydramine : Frequently Asked Questions

Q: Is long-term use of Diphenhydramine safe?

A: Diphenhydramine is intended for short-term use. Do not use diphenhydramine for more than 7 days to treat cold or allergy symptoms (1 Trusted Source
Long-term use of diphenhydramine

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Q: Can Cetirizine and Diphenhydramine be taken together?

A: Diphenhydramine and cetirizine should never be taken together, as this can lead to dangerous complications.

Q: Is it safe to give Diphenhydramine to children?

A: Diphenhydramine should not be given to children younger than 4 years of age. The active ingredient diphenhydramine is an antihistamine, which can be dangerous to children and can cause serious or even fatal side effects (2 Trusted Source
Diphenhydramine : Medlineplus

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Q: Does Diphenhydramine cause dizziness?

A: Diphenhydramine may cause dizziness or drowsiness. As a result, activities requiring mental alertness, such as driving or operating heavy machinery, is not advised (2 Trusted Source
Diphenhydramine : Medlineplus

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Q: Is it safe to take Diphenhydramine during pregnancy?

A: The occasional use of diphenhydramine at recommended doses does not cause problems in pregnancy (3 Trusted Source

Go to source

  • 1. Long-term use of diphenhydramine - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592307/ )
  • 2. Diphenhydramine : Medlineplus - (https://medlineplus.gov/druginfo/meds/a682539.html )
  • 3. Diphenhydramine - (https://www.ncbi.nlm.nih.gov/books/NBK582675/ )
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