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Denosumab - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Denosumab

Generic Name : Denosumab
Pronunciation : den-OH-sue-mab
Latest prescription information about Denosumab. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.4 | Therapeutic Classification : Monoclonal antibodies
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Trade Names/Brand Names of Denosumab

International- Prolia.
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Why is Denosumab Prescribed? (Indications)

This medication is a human monoclonal antibody, prescribed for osteoporosis, treatment induced bone loss, bone metastases, rheumatoid arthritis, multiple myeloma and giant cell tumor of bone. 

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When should Denosumab not be taken? (Contraindications)

Contraindicated in patients with hypocalcemia, multiple myeloma, hypersensitivity and during pregnancy.

What is the dosage of Denosumab?

SC- The recommended dose is 120 mg, for every 4 weeks in the upper arm, upper thigh, or abdomen.

How should Denosumab be taken?

It comes as a solution for injection to be administered by a healthcare provider under the skin.

What are the warnings and precautions for Denosumab?

• Caution should be exercised in patients with history of kidney impairment, anemia, low blood calcium, any allergy, who are taking other medications, thyroid or kidney disease, infection, during pregnancy and breastfeeding.

In some patients, this medication may cause jawbone problems.

Patient may develop Osteonecrosis of the Jaw (ONJ) with the following symptom: gum lesions. If it is so consult with your healthcare provider immediately.

What are the side effects of Denosumab?

   Most Common : Fatigue/weakness, decreased level of phosphate and calcium in blood, nausea, diarrhea, headache and cough.

What are the other precautions for Denosumab?

Avoid excess dosage.

What are the storage conditions for Denosumab?

Store it at room temperature (25C).




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mike65, Canada

what is the price

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