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General Information on Colistimethate Injection

Generic Name : Colistimethate Injection

Pronunciation : koe lis ti meth' ate

Latest prescription information about Colistimethate Injection. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y40 | Therapeutic Classification : Antibacterials and Antibiotics

Why is Colistimethate Injection Prescribed? (Indications)

This medication is a polymyxin antibiotic, prescribed for infections caused by bacteria. The antibiotic fights against the bacteria in the body.  

When should Colistimethate Injection not to be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Colistimethate Injection?

PO- GI infections; Bowel sterilization- 1.5-3 million units 3 times/day.
IV/IM- GI infections; Bowel sterilization as colistimethate Na: 6 million units/day in 3 divided doses. Max: 6-million units/24 hour.
Inhalation- Adjunct to antimicrobial therapy in respiratory infections as colistimethate Na: 1-2 million units twice daily. Max: 2 million units 3 times/day for up to 3 month in frequent recurrent infections.

How should Colistimethate Injection be taken?

It comes as a syrup to take by mouth.

What are the warnings and precautions for Colistimethate Injection?

Caution should be exercised in patients with history of preexisting kidney impairment, disorders of neuromuscular transmission, during pregnancy and lactation.

Monitor liver enzyme level and Blood Urea Nitrogen level regularly while on treatment.

What are the side effects of Colistimethate Injection?

  Gastrointestinal: Gastrointestinal upset.
  Central Nervous System: Tingling of extremities and tongue, slurred speech, dizziness and fainting.
  Skin : Generalized itching, hives and rash.
  Body as a Whole : Fever.
  Respiratory : Respiratory disorder and shortness of breath.
  Genitourinary : Kidney damage and decreased urine output.

What are the other precautions for Colistimethate Injection?

Avoid excess dosage and alcohol consumption.

What are the storage conditions for Colistimethate Injection?

Store reconstituted solution in refrigerator at 2-8C (36-46F) or between 20-25C

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