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General Information on Aprepitant

Generic Name : Aprepitant

Pronunciation : ap-RE-pi-tant

Latest prescription information about Aprepitant. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.0 | Therapeutic Classification : Antiemetics

Trade Names/Brand Names of Aprepitant

India- Aprecap, Aprelief, Apretero, Apriset, Apristar, Emvoid, Empov.
International- Emend.

Why is Aprepitant Prescribed? (Indications)

This medication is an antiemetic, prescribed for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) for prevention of postoperative nausea and vomiting and it is used with other medications to prevent nausea and vomiting that may occur within 24 hours after receiving cancer chemotherapy treatment. Aprepitant works by blocking one of the body's natural substances (substance P/neurokinin 1) that causes vomiting  

When should Aprepitant not to be taken? (Contraindications)

Contraindicated in patients who are taking astemizole, cisapride, pimozide, or terfenadine and hypersensitivity.

What is the dosage of Aprepitant?

PO- The recommended dose is 125 mg, 1 hour prior to chemotherapy treatment (Day 1) and 80 mg orally once daily in the morning on Days 2 and 3.
The recommended oral dosage for post operative nausea is 40 mg within 3 hours prior to induction of anesthesia.

How should Aprepitant be taken?

It comes as a capsule to take by mouth, with or without food.

What are the warnings and precautions for Aprepitant?

Caution should be exercised in patients with history of nausea or vomiting, liver disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.

Do not take aprepitant if you are on following medications, astemizole, cisapride, pimozide, or terfenadine.

It may cause dizziness, do not drive a car or operate machinery while taking this medication.

Avoid alcohol consumption.

What are the side effects of Aprepitant?

   Body as a Whole : Weakness/fatigue, dizziness, dehydration, abdominal pain, fever, hair loss.
   Gastrointestinal : Nausea, constipation, gas, diarrhea, vomiting, heartburn and stomach discomfort/pain.
   ENT : Ringing in the ear.
   Blood : Decrease in white blood cells.
   Metabolic : Loss of appetite, anorexia.
   Central Nervous System : Headache and sleeplessness.
   Heart : Heart burn.    Respiratory : Hiccups.

What are the other precautions for Aprepitant?

Avoid excess dosage.
It is not used to treat nausea and vomiting that you already have.

What are the storage conditions for Aprepitant?

Store it at room temperature (20-25C).

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