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Antithrombin- Recombinant - Indications, Dosage, Side Effects and Precautions

Last Updated on Dec 12, 2011
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Information about Antithrombin- Recombinant

Generic Name : Antithrombin- Recombinant
Pronunciation : AN-tee-THROM-bin
Latest prescription information about Antithrombin- Recombinant. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y44.2 | Therapeutic Classification : Anticoagulants / Antithrombotics
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Trade Names/Brand Names of Antithrombin- Recombinant

International- Atryn.
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Why is Antithrombin- Recombinant Prescribed? (Indications)

This medication is a recombinant human antithrombin, prescribed for prevention of surgical and peri-partum thromboembolic events in hereditary antithrombin deficient patients. It works by regulating the clotting and inflammatory processes that lead to the formation of blood clots. 
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When should Antithrombin- Recombinant not be taken? (Contraindications)

Hypersensitivity to any ingredient in antithrombin (recombinant), or to goat or goat milk proteins.

What is the dosage of Antithrombin- Recombinant?

Dose is based on the patient's pretreatment functional AT activity level and body weight.
Adult- IV- The recommended initial dose is 30-50 IU/kg. Adjust dose according to response.
Administer loading dose as a 15-minute intravenous infusion immediately followed by continuous infusion of the maintenance dose.

How should Antithrombin- Recombinant be taken?

It comes as solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Antithrombin- Recombinant?

• Caution needed for pregnant, breastfeeding women, if you are taking any other medicines, especially any of the anticoagulants (eg, heparin) because the risk of bleeding may be increased by antithrombin (recombinant).

Monitor AT-III levels during treatment.

It may cause dizziness or lightheadedness, do not drive a car or operate machinery while taking this medication.

What are the side effects of Antithrombin- Recombinant?

   Most Common : Nausea, flushing, headache, hemorrhage and infusion site reaction and fever.
   Gastrointestinal : Intra-abdominal hemorrhage.
   Liver : Abnormal levels of hepatic enzyme.
   Musculoskeletal : Hemarthrosis (bleeding into joint places).
   Vascular Disorders : Hematoma (collection of blood outside the blood vessels)
   Central Nervous System : Dizziness and lightheadedness.
   Skin : Hives.
   Genitourinary : Blood in urine.
   Miscellaneous : Chest pain, feeling hot, chills, cramps, and injection site pain.

What are the other precautions for Antithrombin- Recombinant?

Avoid excess dosage.

What are the storage conditions for Antithrombin- Recombinant?

Store it in refrigerator (2-8C). Do not freeze it. Bring vials to room temperature no more than 3 hours prior to reconstitution.



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