This medication is a recombinant human antithrombin, prescribed for prevention of surgical and peri-partum thromboembolic events in hereditary antithrombin deficient patients. It works by regulating the clotting and inflammatory processes that lead to the formation of blood clots.
Hypersensitivity to any ingredient in antithrombin (recombinant), or to goat or goat milk proteins.
Dose is based on based on the patient's pretreatment functional AT activity level and body weight.
Adult- IV- The recommended initial dose is 30-50 IU/kg. Adjust dose according to response.
Administer loading dose as a 15-minute intravenous infusion immediately followed by continuous infusion of the maintenance dose.
It comes as solution for injection to be administered by a healthcare provider into the vein.
• Caution needed for pregnant, breastfeeding women, if you are taking any other medicines, especially any of the anticoagulants (eg, heparin) because the risk of bleeding may be increased by antithrombin (recombinant).
• Monitor AT-III levels during treatment.
• It may cause dizziness or lightheadedness, do not drive a car or operate machinery while taking this medication.
• Most Common :
Nausea, flushing, headache, hemorrhage and infusion site reaction and fever.
• Gastrointestinal : Intra-abdominal hemorrhage.
• Liver : Abnormal levels of hepatic enzyme.
• Musculoskeletal : Hemarthrosis (bleeding into joint places).
• Vascular Disorders : Hematoma (collection of blood outside the blood vessels)
• Central Nervous System : Dizziness and lightheadedness.
• Skin : Hives.
• Genitourinary : Blood in urine.
• Miscellaneous : Chest pain, feeling hot, chills, cramps, and injection site pain.
Avoid excess dosage.
Store it in refrigerator (2-8°C). Do not freeze it. Bring vials to room temperature no more than 3 hours prior to reconstitution.
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