This medication is an endothelin receptor antagonist, prescribed for pulmonary atrial hypertension (high blood pressure in the lungs). The medication blocks the effects of endothelin-1 thereby decreases blood pressure in lungs. The medication also inhibits the thickening of the blood vessel.
♦ Contraindicated in patients with Idiopathic Pulmonary Fibrosis (IPF), pregnant women and known hypersensitivity. It should not be co-administered with cyclosporine.
PO- The initial recommended dose is 5mg once daily with or without food. Maximum: 10mg once daily.
It comes as a tablet to take by mouth, with or without food.
• Caution should be exercised in patients with history of liver or kidney impairment, decreased sperm count, fluid retention, during breastfeeding.
• Monitor liver function, complete blood count regularly while taking this medication.
• Most common :
Peripheral edema, nasal congestion, inflammation of sinuses, flushing, palpitations inflammation of nasopharynx, abdominal pain, nausea, loss of appetite, low fever, itching, constipation and difficulty in breathing.
• Central Nervous System: Headache.
• Blood: Decrease in hemoglobin level.
Avoid excess dosage, and abrupt withdrawal.
Store it at room temperature (25°C), and in an airtight container.