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General Information on Ambrisentan

Generic Name : Ambrisentan

Pronunciation : am-bree-SEN-tan

Latest prescription information about Ambrisentan. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y52.5 | Therapeutic Classification : Anti- Hypertensives

Trade Names/Brand Names of Ambrisentan

India : 

International : 

Letairis

Why is Ambrisentan Prescribed? (Indications)

This medication is an endothelin receptor antagonist, prescribed for pulmonary atrial hypertension (high blood pressure in the lungs). The medication blocks the effects of endothelin-1 thereby decreases blood pressure in lungs. The medication also inhibits the thickening of the blood vessel.  

When should Ambrisentan not to be taken? (Contraindications)

Contraindicated in patients with Idiopathic Pulmonary Fibrosis (IPF), pregnant women and known hypersensitivity. It should not be co-administered with cyclosporine.

What is the dosage of Ambrisentan?

PO- The initial recommended dose is 5mg once daily with or without food. Maximum: 10mg once daily.

How should Ambrisentan be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Ambrisentan?

Caution should be exercised in patients with history of liver or kidney impairment, decreased sperm count, fluid retention, during breastfeeding.

Monitor liver function, complete blood count regularly while taking this medication.

What are the side effects of Ambrisentan?

  Most common : Peripheral edema, nasal congestion, inflammation of sinuses, flushing, palpitations inflammation of nasopharynx, abdominal pain, nausea, loss of appetite, low fever, itching, constipation and difficulty in breathing.
  Central Nervous System: Headache.
  Blood: Decrease in hemoglobin level.

What are the other precautions for Ambrisentan?

Avoid excess dosage, and abrupt withdrawal.

What are the storage conditions for Ambrisentan?

Store it at room temperature (25C), and in an airtight container.

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