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Alglucosidase - Indications, Dosage, Side Effects and Precautions

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Information about Alglucosidase

Generic Name : Alglucosidase
Pronunciation : AL-gloo-KOE-si-dase
Latest prescription information about Alglucosidase. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Enzyme Replacement Therapy
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Trade Names/Brand Names of Alglucosidase

International- Lumizyme and Myozyme.
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Why is Alglucosidase Prescribed? (Indications)

Alglucosidase is an enzyme replacement therapy used for treating Pompe disease, a rare metabolic disorder that damages the muscles and nerves caused due to the accumulation of glycogen in the lysosome.

This medication is a glycoprotein, works by replacing the enzyme alfa-glucosidase in the body. 

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When should Alglucosidase not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Alglucosidase?

The recommended dosage is 20-mg/kg body weight administered every 2 weeks as an intravenous infusion.

How should Alglucosidase be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Alglucosidase?

• Caution should be exercised in patients with history of heart or lung problems, any allergy, who are taking other medications, children, during pregnancy and breastfeeding.

Monitor liver function regularly while taking this medication.

What are the side effects of Alglucosidase?

  Most common: Hives, diarrhea, vomiting, difficulty in breathing, itching, rash, throat and neck pain.
  Blood and lymphatic: Swollen glands.
  Eye and ENT: Hearing loss, ear discomfort or pain and blurred vision.
  Gastrointestinal : Constipation, abdominal pain, indigestion and vomiting.
  General : Chest discomfort or pain, injection site reactions, uneasiness and swelling in the extremities.
  Immune system: Anaphylaxis, infections and stomach inflammation.
  Respiratory : Upper respiratory tract infection, procedural complications and procedural pain.
  Metabolic : Decreased potassium level in blood.
  Musculoskeletal : Muscle twitching, musculoskeletal pain and musculoskeletal stiffness or tightness.
  Central Nervous system: Drowsiness and tremor.
  Genitourinary : Kidney stones.
  Respiratory : Shortness of breath during exercise and nosebleed.
  Skin : Increased sweating.

What are the other precautions for Alglucosidase?

Avoid excess dosage.

What are the storage conditions for Alglucosidase?

Store it in refrigerator (2 to 8C), do not freeze it. Remove the required number of vials from the refrigerator and allow them to reach room temperature prior to reconstitution (approximately 30 minutes).

Last Updated : Jul 2018



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