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Scientists Show How Anti-cancer Drug Works
The drug has previously been shown to be effective in treating Wilson disease, a disease caused by an overload of copper, and certain metastatic cancers. However, little is known about how the drug works at the molecular level.
Copper is an important cofactor for tumor angiogenesis, the process of growing new blood vessels to feed the tumor. Researchers believe this is why tetrathiomolybdate has shown promise as an anti-cancer drug.
In the new study, researchers found that three-dimensional structure of TM bound to copper-loaded metallochaperones. The drug sequesters the chaperone and its bound copper, preventing both from carrying out their normal functions in the cell.
For patients with Wilson disease and certain cancers whose initial growth is helped by copper-dependent angiogenesis, this is very promising.
Researchers hope that the new findings would opens the door to the development of new classes of pharmaceutical agents based on metal trafficking pathways, as well as the further development of more efficient TM-based drugs.
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11/30/2009
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Hats off to the researchers for their pain-staking efforts to render remedy for malignant tumours.The in-depth research work is very much useful to the mankind.
On the other hand, research may be encouraged to study Rigveda [one of 4 vedas, namely, Samaveda, Yajurveda, Atharvaveda] which dealt with Ayurveda and acupressure.
If allopathy peeps into our Hindu Upanishads found 5000 years ago, they can as well find wonderful remedies for all the diseases of the mankind. The cost shall be affordable and they can as well tackle the demon of side effects.
For the young,dynamic and open-minded Indian allopaths, it is quite feasible with their easy access and excellent knowledge of human anatomy and physiology and pharmacology; to peep into our scriptures and lead the world of scientists to find excellent remedies for the human sufferings.Indian intelligence is second to none.