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Apomorphine

Latest prescription information about Apomorphine. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Apomorphine
Pronunciation : a poe mor' feen
Therapeutic Classification : Antiparkinson Agents
ICD Code : Y46.7
Trade Name(s): 
International- Apokyn
Why it is prescribed (Indications) : 
This medication is a non-selective dopamine agonist, prescribed for Parkinson disease. In some cases this medication is used in the treatment of erectile dysfunction. The medication activates the dopamine receptors in the brain. 
When it is not to be taken (Contraindications): 
Hypersensitivity, co-administration with Ondansertron.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
SC: The recommended initial dose is 0.2ml(2mg), 3times/day.
Test dose is recommended.
How it should be taken : 
It comes as a solution for injection, to be administered by a healthcare provider subcutaneously.
Warnings and Precautions : 
* It may cause involuntary movement or worsening of the condition.
* Caution should be exercised in patients with history of allergy, who are taking other medications, asthma, eye disease, fainting spells, irregular heartbeat, low blood pressure, mental illness, sleep disorder, stroke or mini-stroke, or other brain problems, sudden uncontrolled movements and falls, or heart, kidney, liver or lung disease, during pregnancy and breastfeeding.
* It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication and get up slowly from bed.
Side Effects : 
Most Common- Yawning, involuntary movements, nausea, vomiting, bruising, redness at the injection site region, drowsiness, dizziness, runny nose, hallucinations, swelling, chest pain, increased sweating, flushing and pallor.
Body as Whole- Weakness and dehydration.
Central Nervous System- Sleeplessness, headache, depression, anxiety, worsening of Parkinson disease, confusion and fatigue.
Musculoskeletal- Muscle/Joint pain, limb pain and back pain.
Gastrointestinal- Constipation and diarrhea.
Heart- Congestive heart failure.
Respiratory- Difficulty in breathing.
Genitourinary- Urinary tract infection.
Other Precautions : 
* Avoid alcohol consumption while taking this medication.
Storage Conditions : 
Store it at room temperature (25°C), and in an airtight container. Keep away from children.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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