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Generic Name : Ambrisentan
Pronunciation : am-bree-SEN-tan
Trade Name(s):
International- Letairis. This medication is an endothelin receptor antagonist, prescribed for pulmonary atrial hypertension (high blood pressure in the lungs). The medication blocks the effects of endothelin-1 thereby decreases blood pressure in lungs. The medication also inhibits the thickening of the blood vessel. When it is not to be taken (Contraindications):
When it is to be taken : PO- The initial recommended dose is 5mg once daily with or without food. Maximum: 10mg once daily. How it should be taken : It comes as a tablet to take by mouth, with or without food. Special Instruction : * Caution should be exercised in patients with history of liver or kidney impairment, decreased sperm count, fluid retention, during breastfeeding. * Monitor liver function, complete blood count regularly while taking this medication. Side Effects : Most common - Peripheral edema, nasal congestion, inflammation of sinuses, flushing, palpitations inflammation of nasopharynx, abdominal pain, nausea, loss of appetite, low fever, itching, constipation and difficulty in breathing. Central Nervous System- Headache. Blood- Decrease in hemoglobin level. * Avoid excess dosage, and abrupt withdrawal. Storage Conditions : Store it at room temperature (25 °C), and in an airtight container. |
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