Medindia » Consumer Health » Medication Manual » Ambrisentan

Ambrisentan

Latest prescription information about Ambrisentan. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Email Email Save this page Save Syndicate Syndicate
Generic Name : Ambrisentan
Pronunciation : am-bree-SEN-tan
Trade Name(s): 
International- Letairis.
Why it is prescribed (Indications) : 
This medication is an endothelin receptor antagonist, prescribed for pulmonary atrial hypertension (high blood pressure in the lungs). The medication blocks the effects of endothelin-1 thereby decreases blood pressure in lungs. The medication also inhibits the thickening of the blood vessel.

When it is not to be taken (Contraindications): 


Contraindicated in pregnant women, co administration with cyclosporine A; hypersensitivity.

Pregnancy Category :

A B C D X
Category X : Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.


When it is to be taken : 
PO- The initial recommended dose is 5mg once daily with or without food. Maximum: 10mg once daily.
How it should be taken : 
It comes as a tablet to take by mouth, with or without food.
Special Instruction : 
* Caution should be exercised in patients with history of liver or kidney impairment, decreased sperm count, fluid retention, during breastfeeding.
* Monitor liver function, complete blood count regularly while taking this medication.
Side Effects : 
Most common - Peripheral edema, nasal congestion, inflammation of sinuses, flushing, palpitations inflammation of nasopharynx, abdominal pain, nausea, loss of appetite, low fever, itching, constipation and difficulty in breathing.
Central Nervous System- Headache.
Blood- Decrease in hemoglobin level.
Other Precautions : 
* Avoid excess dosage, and abrupt withdrawal.
Storage Conditions : 
Store it at room temperature (25 °C), and in an airtight container.

Comment & Contribute
Comments should be on the topic and should not be abusive. Comments are normally moderated and are reviewed after they are posted.
* Your comment can be maximum of 2500 characters
I agree to the terms and conditions
If you have a question about health related issues, you can now post it in our Ask An Expert section on our community website Medwonders.com and get answers from our panel of experts.

Browse the Drugs alphabetically

Drugs Index
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Price List