Trade Names/Brand Names :
AccuNeb , Proventil, Proventil HFA , Ventolin HFA, Vospire ProAir, Albuterol Sulfate
Why it is prescribed :
This medication is a short-acting β2-adrenergic receptor agonist, used to prevent and treat wheezing, shortness of breath, coughing, and chest tightness caused by lung diseases such as asthma and chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways It relaxes the smooth muscles in the airway, which allows air to flow in and out of the lungs more easily. Salbutamol has been used in treating acute hyperkalemia on account of its potassium-depleting properties by stimulating potassium inflow in cells.
When it is not to be taken (Contraindications):
Category C :
Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.
Dosage & When it is to be taken (Indications):
PO- The usual starting dose is 1.25 mg or 0.63 mg, 3 or 4 times daily.
The emergency room treatment is a massive dose of Salbutamol given by aerosol nebulization in doses of > 7.5 mg / hour and continued until the side effects of tremor or tachycardia are evident in patients.
Usual Adult Albuterol Dose for Acute Asthma and Acute Chronic Obstructive Pulmonary Disease - Metered-dose inhaler: 2 puffs every 4 to 6 hours as needed.
Inhalation capsules: 200 mcg inhaled every 4 to 6 hours and may increase to 400 mcg inhaled every 4 to 6 hours, if necessary.
Bronchospasm Prophylaxis: Metered-dose inhaler: 2 puffs (180 or 216 mcg) 15 minutes before exercise.
Inhalation capsules: 200 mcg inhaled 15 minutes before exercise.
Less than 1 year: Nebulizer: 0.05 to 0.15 mg/kg/dose every 4 to 6 hours with subsequent doses titrated based on clinical response.
1 year to 4 years: Nebulizer: 1.25 to 2.5 mg every 4 to 6 hours with subsequent doses titrated based on clinical response.
5 years or older: Metered-dose inhaler (HFA): 2 puffs (216 mcg) every 4 to 6 hours as needed. Inhalation capsules: 200 mcg inhaled every 4 to 6 hours and may increase to 400 mcg inhaled every 4 to 6 hours, if necessary.
12 years or older: Nebulizer: 2.5 to 5 mg every 6 hours as needed.
How it should be taken :
It comes as a tablet, capsule and syrup to take by mouth, on an empty stomach.
It also comes as a solution for injection to be administered by a healthcare provider either into the large muscle or under the skin.
Warnings and Precautions :
• Caution should be exercised in patients with history of heart disease, high blood pressure, or congestive heart failure, a heart rhythm disorder; epilepsy, diabetes, overactive thyroid, kidney problems, adrenal gland tumor, who are taking other medications, any allergy, elderly, children, during pregnancy and breastfeeding.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.
An inhaler should not be given to a child younger than 4 years old.
Albuterol solution in a nebulizer should not be given to a child younger than 2 years of age.
Side Effects :
• Most Common
Tremor, anxiety, headache, muscle cramps, dry mouth, and palpitations.
• Central nervous system
Sleeplessness, weakness, dizziness, drowsiness.
Fast / slow heart rate, flushing and chest pain.
Muscle cramps, muscle, bone or back pain.
Nausea, worsening of diabetes, vomiting.
Inflammation of bronchus, nose bleed, cough and throat irritation.
Allergic reactions and rash.
Flu symptoms, metabolic acidosis
Other Precautions :
This medication may affect blood sugar level; monitor blood sugar level regularly.
Avoid excess dosage.
Storage Conditions :
Store it at controlled room temperature (between 2°C and 25°C). Protect from light and excessive heat.
Schedule : H
Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.
♦ Safety Labeling Changes Approved By FDA