Trade Names/Brand Names :
Aclacinon, Aclacin, Aclacinomycine, Aclaplastin, Jaclacin
Why it is prescribed :
This medication is an anthracycline agent, prescribed for acute non-lymphocytic leukaemia. It has a selective inhibitory effect on the synthesis of RNA in the cells
When it is not to be taken (Contraindications):
Contraindicated in patients with severe heart disease, bone marrow depression, and hypersensitivity.
Category D :
There is an evidence of fetal risk based on adverse reaction data, but potential benefits may allow the drug to be used in pregnant women despite risks.
Dosage & When it is to be taken (Indications):
Adult: IV- Initial: 175-300 mg/m2
, divided over 3-7 consecutive days. Maintenance: 25-100 mg/m2
How it should be taken :
It comes as a solution for injection to be administered by a healthcare provider into the vein.
Warnings and Precautions :
• Caution should be exercised in patients with history of liver or kidney impairment, radiation-induced heart attack, and use of radiotherapy, during pregnancy and breastfeeding.
Monitor complete blood counts, liver function, uric acid level in blood regularly while taking this medication.
Side Effects :
• Severe Effects
Heart damage and bone marrow suppression.
Nausea, vomiting, irritant to tissue, sore mouth, diarrhea, and gastrointestinal tract inflammation.
Anemia, bone-marrow suppression.
: Hepatic dysfunction.
Blood in urine.
Other Precautions :
Avoid live vaccination during the treatment period.
Avoid excess dosage.
Storage Conditions :
IV Inj: Store at room temperature (20 to 25°C). Protect from sunlight.
IV Inj (reconstituted solution): Store below 40°C. Use within 24 hours if kept at room temperature.
Schedule : H
Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.