Acetazolamide - Drug Information

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Generic Name : Acetazolamide

Pronunciation : (a set a zole'a mide)

Latest prescription information about Acetazolamide. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y54.5 | Therapeutic Classification : Diuretics

Trade Name(s): 

India : 

More...

International : 

Abzole, Acetamide Tab, Acetamin Tab, Acetariv Tab, Avva Sr-Cap, Avva Tab, Diamox Tab, Iopar-Sr Cap, Synomax Tab, Zolamide Tab

Why it is prescribed : 

This medication is a carbonic anhydrase inhibitor, prescribed for glaucoma, edema due to congestive heart failure, epileptic seizure, idiopathic intracranial hypertension (a.k.a. pseudotumor cerebri), cystinuria, periodic paralysis, central sleep apnea and dural ectasia. It is also used to prevent and reduce the symptoms of altitude or acute mountain sickness and moderate to severe metabolic or respiratory alkalosis. This medication reduces the activity of carbonic anhydrase protein. 

When it is not to be taken (Contraindications): 

Contraindicated in patients with adrenal gland problems, low levels of potassium or sodium in blood, kidney problems, liver problems, high levels of chloride in blood, electrolyte problems and hypersensitivity.

Pregnancy Category :

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

Dosage & When it is to be taken (Indications): 

The dose ranges from 250 mg to 1 g of acetazolamide for 24 hours, usually in divided doses for amounts over 250 mg.
Adult- PO Diuresis 250-375 mg/day. Glaucoma; Epilepsy 250-1,000 mg/day. Prophylaxis of high altitude sickness 500-1,000 mg/day. IV Chronic open angle glaucoma 250-1000 mg 24 hrly and Epilepsy 8-30 mg/kg/day in divided doses.

How it should be taken : 

It comes as a tablet and capsule, to take by mouth with food. If you are taking the extended-release form of acetazolamide, do not crush or chew the capsules.

Warnings and Precautions : 

Caution should be exercised in patients with history of kidney stones, sickle cell anemia, lung diseases, increased eye pressure, respiratory problem, elderly, who are taking other medications, any allergy, during pregnancy and breastfeeding.
It may cause dizziness, drowsiness or vision changes, do not drive a car or operate machinery while taking this medication.
Limit alcoholic beverages.
Avoid exposure to sunlight.
Monitor blood sugar, complete blood cell count regularly while taking this medication.
This medication should not be used in children less than 12 because it may affect normal growth.
Caution is advised for patients receiving concomitant high-dose aspirin and acetazolamide, as anorexia, tachypnea, lethargy, coma and death have been reported.

Side Effects : 


   Most Common
- Numbness and tingling in the fingers and toes, tiredness, loss of appetite,dry mouth, headache, nausea, vomiting, stomach pain.

  Central Nervous System
- Occasional instances of drowsiness and confusion, and seizures.

  ENT
- Taste alterations (parageusia) especially for carbonated drinks, sore throat, ringing in the ear, and Some may also experience blurred vision but this usually disappears shortly after discontinuing the medication.

  Genitourinary
- Blood in stool/urine, dark urine, painful urination and excessive passage of urination.

  Metabolic
- Liver impairment, increases the risk of kidney stones, metabolic acidosis, increased thirst, and electrolyte imbalance.

  Skin
- Hives, unusual bleeding or bruising and photosensitivity.

Other Precautions : 

Avoid excess dosage.

Storage Conditions : 

Store at 20-25C (68-77F). Excursions permitted to 15-30 in an airtight container. Keep it out of reach of children.


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jaya1122 Thursday, March 7, 2013

Why has it been prescribed for a person after cataract surgery of the left Eye

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