The disease is caused by one of four closely related, but antigenically distinct, virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4).
Due to serotype specificity infection with one serotype does not provide cross-protective immunity to other serotype, so persons are theoretically susceptible to have four dengue infections during their lifetime.
Dengue viruses are transmitted from person to person by a domestic mosquito called - Aedes aegypti.
Infection with dengue viruses causes clinical illness ranging from a less dangerous non-specific viral syndrome called 'Dengue fever' to severe and fatal hemorrhagic disease of 'Dengue Hemorrhagic Fever (DHF)'.
The severity and risk factors for DHF depends upon:
• Strain and serotype of the infecting virus
• Immune status
• Genetic predisposition of the patient. Dengue Hemorrhagic Fever (DHF) is the most severe form of dengue, which can be fatal if unrecognized and not properly treated; DHF is caused by infection with the same viruses that cause dengue.
Latest Publications and Research on Dengue / Dengue Hemorrhagic FeverVitamin D Receptor polymorphisms and risk of enveloped virus infection: A meta-analysis. - Published by PubMed
An ensemble forecast model of dengue in Guangzhou, China using climate and social media surveillance data. - Published by PubMed
Ten-years trend of dengue research in Indonesia and South-east Asian countries: a bibliometric analysis. - Published by PubMed
Blockade of dengue virus entry into myeloid cells by endocytic inhibitors in the presence or absence of antibodies. - Published by PubMed
Exhaustive TORCH Pathogen Diagnostics Corroborate Zika Virus Etiology of Congenital Malformations in Northeastern Brazil. - Published by PubMed