Lactose intolerance is the inability to digest lactose, the sugar in milk. This leads to gastrointestinal symptoms (diarrhoea, abdominal cramps) when milk or milk products are consumed.
The condition arises due to a defect in the digestive enzyme called lactase. Children with lactose intolerance have diarrhea and may not gain weight. In adults the symptoms include abdominal bloating, cramps, diarrhea, flatulence, nausea, audible bowel sounds (borborygmi) and an urgent need to have a bowel movement. Diagnosis is based on symptoms. Avoiding lactose and supplementing lactase enzymes are the usual treatments.
75% of the world’s population is estimated to suffer the deficiency. Prevalence is higher prevalence among Asian, African, and South American persons.
Males and females are equally affected by lactose intolerance. Among adults, the age of presentation of intolerance is 20-40 years.
About 44% of the women with lactose intolerance regain the ability to digest lactose during pregnancy. The condition is associated with very little morbidity.
- Cecil Medicine, 23rd Ed.
- The Merck Manual, 18th Ed.
Latest Publications and Research on Lactose Intolerance
- Carboxymethylpachymaran-zein coated plant microcapsules-based ß-galactosidase encapsulation system for long-term effective delivery. - Published by PubMed
- Lactose induced redox-dependent senescence and activated Nrf2 pathway. - Published by PubMed
- Roles of Lactose and Fructose Malabsorption and Dietary Outcomes in Children Presenting with Chronic Abdominal Pain. - Published by PubMed
- The cryo-EM Structure of Thermotoga maritima ß-Galactosidase: Quaternary Structure Guides Protein Engineering. - Published by PubMed
- Lactose Malabsorption and Lactose Intolerance in Children with Inflammatory Bowel Diseases. - Published by PubMed