A family of protein transcription factors, called Forkhead (Fox0) , that plays a vital role in the regulation of skeletal muscle mass has been identified by scientists.
A family of protein transcription factors, called "Forkhead (Fox0)", that plays a vital role in the regulation of skeletal muscle mass has been identified by scientists. Specifically, University of Florida researchers found that interfering with the activity of these transcription factors prevents muscle wasting associated with cancer and sepsis, and even promotes muscle growth.
This discovery is likely to be relevant to any disease, condition or lifestyle that leads to muscle wasting, including voluntary inactivity.
"The loss of muscle mass is a major contributor to disease-related deaths," said Andrew R. Judge, Ph.D., a researcher involved in the work from the Department of Physical Therapy at the University of Florida in Gainesville.
"FoxO proteins may provide a target for therapies aimed at reducing muscle wasting and thus improving the quality of life and survival rates for patients with many different diseases."
To make this discovery, Judge and colleagues genetically inhibited the activity of "Forkhead boxO" proteins, or "FoxO," in the skeletal muscle of healthy control mice, septic mice, and mice with cancer.
The loss of muscle mass in those with cancer and sepsis was significantly decreased by inhibition of FoxO activity.
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"No one can deny that the human body was meant to move, and to move often," said Gerald Weissmann, M.D., Editor-in-Chief of the Journal, "but the reality is that many of us don't move enough, whether because of disease, injury, or simply a busy schedule."
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The study has been published in the FASEB Journal.
Source-ANI