About My Health Careers Internship MedBlogs Contact us

Vitamin D Levels Linked to Gut Bacteria

by Pooja Shete on December 3, 2020 at 4:06 PM
Font : A-A+

Vitamin D Levels Linked to Gut Bacteria

In older men, the gut microbiome was associated with levels of active vitamin D, a hormone which is essential for bone health and immunity, stated research conducted by University of California San Diego and collaborators. Many bacteria, viruses and other microbes are present in gut called as microbiomes. The study was published in Nature Communications.

Vitamin D exists in different forms in the body. The standard blood tests measure the inactive form that can be stored in the body.


Senior author Deborah Kado, MD, director of the Osteoporosis Clinic at UC San Diego Health said, "We were surprised to find that microbiome diversity — the variety of bacteria types in a person's gut — was closely associated with active vitamin D, but not the precursor form. Greater gut microbiome diversity is thought to be associated with better health in general."

Multiple studies have been conducted that show lower vitamin D levels are linked with higher risk of cancer, heart disease, severe COVID-19 infection and many other diseases.

One of the largest clinical trial of 25,000 patients has concluded that taking vitamin D supplements have no effect on health outcomes like heart disease, cancer and even bone health.

567 men who lived in six different cities across the US, having a mean age of 84 and having good or excellent health participated in the study MrOS. Their stool samples were analyzed using a technique called 16s rRNA sequencing to identify and quantify the types of bacteria in each stool sample based on unique genetic identifiers. For the blood samples a technique called LC-MSMS was used to quantify vitamin D metabolites- the precursor, active hormone and the breakdown product.

The researchers also noted that in the gut microbiomes of men who have an increased level of active vitamin D, 12 particular types of bacteria appear more often. Most of these 12 bacteria help to maintain the gut lining health by producing fatty acid butyrate.

Jiang said, "Gut microbiomes are really complex and vary a lot from person to person. When we do find associations, they aren't usually as distinct as we found here."

The men enrolled in the study were exposed to different amounts of sunlight, as they lived in different cities, which is source of vitamin D but the researchers found no correlation between where the men lived and their levels of active vitamin D.

Kado added that the study was based on a single snapshot in time of the microbes and vitamin D found in participants' blood and stool. Factors that can affect the active vitamin D level include diet, environment, medications, sleep habit and more.

Additional research is needed to better understand the part bacteria play in vitamin D metabolism and also to determine whether intervening at the microbiome level can be used to supplement the current treatment options to improve bone and possibly other health outcomes.

Source: Medindia

News A-Z
News Category
What's New on Medindia
Black Tea Protects against Blood Pressure and Heart Diseases
Green Mediterranean Diet may Help Repair Age-Related Brain Damages
Cervical Cancer Awareness Month 2022
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Calcium and Vitamin Supplements Rickets Vitamin Supplements Vitamin C / Ascorbic acid Vitamin B6 Vitamin B9 Vitamin B-12 Shigellosis Vitamin-F MRSA - The Super Bug 

Recommended Reading
Novel Insight into a Placental Gene Pathway and Its Link With Vitamin D
Preeclampsia-related gene expression in the placenta may correlate with vitamin D status during ......
Vitamin D, Fish Oil Don't Reduce Atrial Fibrillation Risk
Neither omega-3 fatty acids nor vitamin D found in fish oil could prevent the atrial fibrillation .....
Vitamin D Regulates Calcium in the Intestine Differently than Previously Thought
Vitamin D regulates calcium in a part of the intestine previously thought not to have played a key ....
Vitamin D and Omega-3s Boost Health in Some Active Older People
Vitamin D and Omega-3 supplements help older people avoid COVID-19 infection by boosting their ......
Calcium and Vitamin Supplements
Calcium and vitamin supplements are taken to provide the body with the ''required'' nutrients. Calci...
MRSA - The Super Bug
MRSA infection is the most dreaded hospital or community acquired infection that can become ......
Encyclopedia section of medindia explains in brief about Rickets...
Shigellosis or Bacillary Dysentery is a common cause of gastro-enteritis worldwide and can cause blo...
Vitamin B-12
Vitamin B-12 is also known as cobalamine or cyanocobalamine, owing to the presence of the metal, cob...
Vitamin B6
Vitamins play an equally important part in the synthesis of neurotransmitters. Neurotransmitters in ...
Vitamin B9
Vital info about vitamin B9, its molecular structure, dietary sources, beneficial aspects, symptoms ...
Vitamin C / Ascorbic acid
Vital info about vitamin C, its molecular structure, dietary sources, beneficial aspects, symptoms o...
Vitamin Supplements
Easy to understand info & tips with diagrams about vitamin supplements like vitamin C, B6, B9 & B12....
Essential fatty acids - omega 3 and omega 6 are sometimes referred to as Vitamin F. The body is not...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)