About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Gut Microbes Important For Normal Sleep

by Pooja Shete on December 3, 2020 at 3:41 PM
Font : A-A+

Gut Microbes Important For Normal Sleep

With the holiday season approaching, many people ask the question what is the relationship between food and sleep. Researchers at the University of Tsukuba in Japan led by Professor Masashi Yanagisawa studied the role of bacterial microbes in the gut. They performed a detailed study in mice that showed the extent to which bacteria can change the environment and contents of the intestines, which have a effect on behaviors like sleep.

The researchers depleted the intestinal microorganisms of the mice by giving them a powerful cocktail of antibiotics for four weeks. Comparison of the intestinal content between these mice and control mice (not given antibiotics) was done.

Advertisement


Microorganisms help in the digestion, which breaks food down into smaller pieces called metabolites. Significant differences between the metabolites were found in the microbiota-depleted mice and the control mice.

Professor Yanagisawa said, "We found more than 200 metabolite differences between mouse groups. About 60 normal metabolites were missing in the microbiota-depleted mice, and the others differed in the amount, some more and some less than in the control mice."
Advertisement

The next goal of the team was to determine the function of these metabolites. Using a method called metabolome set enrichment analysis, it was observed that the biological pathways which were affected by the antibiotic treatment were those involved in producing neurotransmitters. Neurotransmitters are molecules used by the nerves to communicate with each other.

The tryptophan-serotonin pathway, (produces serotonin that is important for well-being and mood) was shut and the microbiota-depleted mice had no serotonin but had high levels of tryptophan as they could not metabolize tryptophan to produce serotonin. Deficiency of vitamin B6 metabolites was also seen in these mice which accelerates the production of serotonin and dopamine.

Brain activity using EEG (Electroencephalogram) was used to analyze the sleeping pattern of the mice and it was observed that when compared to control mice, microbiota-depleted mice had more REM and non-REM sleep at night. Microbiota-depleted mice frequently switched between the sleep-wake stages than the control mice.

The lack of serotonin is responsible for the abnormal sleep but the exact mechanism is not known.

Professor Yanagisawa said, "We found that microbe depletion eliminated serotonin in the gut, and we know that serotonin levels in the brain can affect sleep/wake cycles. Thus, changing which microbes are in the gut by altering diet has the potential to help those who have trouble sleeping."

Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Black Pepper as Preventive Measure Against Omicron
FODMAP Diet: A Beginner's Guide
Smallpox
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Snoring Sleep Disorder : Restless Legs Syndrome Sleep Disorder: Sleepwalking Periodic Limb Movement Disorder REM Behavior Disorder Sleep Disturbances In Women Sleep Insomnia Obstructive Sleep Apnea Sleep Disorders: A Prelude 

Recommended Reading
Mother's Prenatal Psychological Distress is Tied to Infant Gut Microbes
Mother's chronic prenatal stress and elevated hair cortisol concentrations are linked to the ......
Diet, Gut Microbes can Affect Cancer Therapy Outcomes
Diet can cause microbes in the gut to trigger changes in the cancer patients' response to a ......
Smoking at Night: Good or Bad for a Healthy Sleep?
Smoking at night can reduce the sleep time by at least 48 mins. Smoking between 11.00 pm to 2.00 am ...
Sleep Helps Teens With Migraine
Starting school later in the morning was found to help teenagers with migraine issues, a new study ....
Insomnia
Difficulty in initiating and maintaining sleep is known as insomnia. It is a symptom that occurs due...
Obstructive Sleep Apnea
Obstructive sleep apnea should be suspected in overweight middle aged adults who snore loudly and w...
Periodic Limb Movement Disorder
Periodic limb movement disorder (PLMD) is a sleep disorder which causes repetitive cramping or jerki...
REM Behavior Disorder
REM Behavior Disorder (RBD) is a sleep disorder in which the person acts out dramatic or violent dre...
Sleep
Sleep is a behavioral state of restricted physical activity. It is controlled by our internal biolo...
Sleep Disorder : Restless Legs Syndrome
Restless legs syndrome (RLS) causes - An urge to move, usually due to uncomfortable sensations that...
Sleep Disorder: Sleepwalking
Sleepwalking or “Somnambulism,” is a type of parasomnia and has medico-legal implications...
Sleep Disorders: A Prelude
Sleep disorders include difficulty falling/staying asleep, falling asleep at inappropriate times, ex...
Sleep Disturbances In Women
The physical, emotional and hormonal changes that occur in women during puberty, menstrual cycle, pr...
Snoring
Turbulent airflow causes tissues of the nose and throat to vibrate and the noise produced by these v...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use