Vitamin D Has No Effect for Asthma Attacks in Children

Vitamin D was previously thought to reduce asthma attacks in children. A recent clinical trial found that vitamin D had no effect for severe asthma attacks in at-risk children.

Vitamin D supplements do not prevent severe asthma attacks in at-risk children, according to the first clinical trial to test this relationship.

These results were published in JAMA.

Fat Deposition in Lungs of Obese People May Up Asthma Risk
Fat accumulation in the walls of the lungs occurs in obese individuals. This can change the structure of the airways, thereby increasing the risk of asthma. However, this could be prevented by maintaining a healthy body weight.

"The reason that's important is there are colleagues around this country and worldwide who are testing vitamin D levels for kids with asthma and giving them vitamin D," said study lead author Juan C. Celedón, M.D., Dr.P.H., chief of pediatric pulmonary medicine at UPMC Children's Hospital of Pittsburgh.

"As a system, it costs a lot of money to run all these tests and give the supplements. We've shown no benefit for children with moderately low vitamin D levels."

For three years, the Vitamin-D-Kids Asthma (VDKA) Study followed nearly 200 children ages 6 to 16 across seven different U.S. hospital systems. All had at least one asthma attack during the year before the study began.

New Treatment for Asthma and Inflammatory Lung Disease
Activation of a protein that helps control blood glucose levels, plays a vital role in treating asthma and inflammatory lung disease.

Half of the participants were randomized to receive 4,000 IU of vitamin D per day, and the other half got placebo pills. No one involved in the study knew which type of pill each participant was getting.

All of the children had vitamin D levels low enough that supplements should have an effect -- if vitamin D truly is beneficial for reducing severe asthma attacks -- but the study excluded children with severe vitamin D deficiency because it would be unethical to withhold it in those cases.

World Asthma Day
World Asthma Day is observed on the first Tuesday of May annually across the world. This year 2020, the day is celebrated on 5th May. It aims to educate the general public and create awareness about asthma and to support persons with asthma and their families cope better with the condition.

Compared to placebo, vitamin D did not reduce the number of asthma attacks participants experienced or their reliance on inhaled steroids.

That's different from what was seen in the past with observational studies in Costa Rica, the U.S. and Canada, and Puerto Rico, where children with naturally low vitamin D levels seemed to have worse asthma.

Plant-based Diet can Ward Off Asthma
Want to get rid of asthma naturally? Eating a plant-based diet every day can help prevent and manage asthma symptoms. On the other hand, eating more dairy products and foods high in saturated fat can raise asthma risk.

"With observational studies, you never know -- is vitamin D causing asthma to be worse or do kids with worse asthma end up having lower vitamin D?" said Celedón, who also holds the Niels K. Jerne chair of Pediatrics at the University of Pittsburgh School of Medicine.

Even with the rigor of the present study's design, Celedón acknowledges that he can't draw conclusions about whether very low vitamin D levels contribute to asthma attacks, but he argues that those children would be supplemented either way because of known effects on bone health.

Source-Eurekalert