About Careers MedBlog Contact us
New Treatment for Asthma and Inflammatory Lung Disease

New Treatment for Asthma and Inflammatory Lung Disease

Font : A-A+

  • New class of drugs can reverse asthma and chronic obstructive pulmonary disease (COPD) symptoms
  • Drugs activate free fatty acid receptor 4 (FFA4) in the lungs
  • Activation of FFA4 leads to reduced inflammation and increased air flow in the lungs

Novel class of drugs capable of reversing the symptoms of asthma and chronic obstructive pulmonary disease (COPD) have been discovered by a group of scientists.

The research findings are published in Science Translational Medicine .

Listen to this article

New Treatment for Asthma and Inflammatory Lung Disease

Mechanism of Action of the Drugs
The team led by University of Glasgow used drugs that work through a mechanism unique from other commonly prescribed medicines for asthma and COPD.

The researchers describe an alternate treatment for patients with severe forms of asthma and COPD.

Free fatty acid receptor 4 (FFA4), a protein in the gut and pancreas is known to respond to fats contained in our diet. FFA4 is generally activated by fats in the diet like fish oil omega 3. It is known to aid control the levels of blood glucose.

FFA4 was discovered in the human lungs by the team.

A new class of drugs that can activate FFA4 in the lungs were designed. Research Findings

The novel drugs resulted in the muscle that surrounds the airways relaxed to allow more air to enter the lung.

Activators of FFA4 also reduced inflammation in mice exposed to pollution, cigarette smoke and allergens that cause asthma.

The researchers concluded that activating FFA4 can reverse hallmarks of inflammatory lung disease.

In summary, around 5.4 million people in the UK are receiving asthma treatment: 1.1 million children and 4.3 million adults.

"By the identification of this new mechanism we offer the hope for new effective medicines for those patients who are not responsive to our current treatments," said Christopher Brightling, from the University of Leicester.

The researchers are very optimistic on extending their findings to develop a new drug treatment for asthma and COPD.

Source: Medindia

Cite this Article   close



Recommended Reading

Latest Health In Focus

A Non Invasive Screening Test for Fetal Genetic Anomalies: Cell-Free DNA Testing
Cell-free DNA analysis of maternal plasma is easy ,non- invasive and highly effective in detecting fetal chromosomal and genetic abnormalities in antenatal mothers
Include Eggs in Your Diet to Lower the Risk of Heart Disease
Including eggs in your diet can reduce the risk of heart disease by 60-75% and also improve blood sugar levels
Possible Genetic Link Between Migraine and Blood Sugar Levels
A new genetic link between migraine and mismanaged blood sugar levels is confirmed. It can help discover new treatments
Decoding Key Reasons For a Longer Life Span
The most important factors for a longer and healthier life span are nutrient dense diet, physical exercise, stress free lifestyle, and genetics to some extent
Half - Moon Pose for a Stable, Stress-Free Mind
Ardha Chandra asana, or the half- moon pose is known to improve flexibility and balance. It also relieves stress and promotes peace of mind
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

New Treatment for Asthma and Inflammatory Lung Disease Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests