Using Injections for Diabetes and Cancer Might be Avoidable

Paving the way for diabetes and cancer patients to forget needles and injections, and instead take pills to manage their conditions is shown by Researchers at UC Riverside, US. Some drugs for these diseases dissolve in water, so transporting them through the intestines, which receive what we drink and eat, is not feasible.

As a result, these drugs cannot be administered by mouth. However, UCR scientists have created a chemical ‘tag’ that can be added to these drugs, allowing them to enter blood circulation via the intestines.

The details of how they found the tag, and demonstrations of its effectiveness, are described in a new Journal of the American Chemical Society paper.

Hate Needles? Diabetic and Cancer Patients may try Pills

The tag is composed of a small peptide, which is like a protein fragment. Because they are relatively small molecules, you can chemically attach them to drugs, or other molecules of interest, and use them to deliver those drugs orally.

While researchers were testing something unrelated in the laboratory, they observed these peptides making their way into cells.

This observation was unexpected because they believed that this type of delivery tag needed to carry positive charges to be accepted into the negatively charged cells. Their work with this neutral peptide tag, called EPP6, shows that belief was not accurate.

Testing the peptide’s ability to move through a body, the Xue group teamed up with Kai Chen’s group in the Keck School of Medicine at the University of Southern California and fed the peptide to mice.

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Using a PET scan — a technique similar to a whole-body X-ray that is available at USC, the team observed the peptide accumulating in the intestines and documented its ultimate transfer into the animals’ organs via the blood.

Having proven the tag successfully navigated the circulatory systems through oral administration, the team now plans to demonstrate that the tag can do the same thing when attached to a selection of drugs. Quite compelling preliminary results can push this further.

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Many drugs, including insulin, must be injected. The researchers are hopeful their next set of experiments will change that, allowing them to add this tag to a wide variety of drugs and chemicals, changing the way those molecules move through the body. This discovery could lift a burden on people who are already burdened with illness.



Source-Eurekalert