The use of supplements among US adults has stabilized. This stabilization appears to be the balance of several opposing trends that decreased the use of multivitamins.

‘More than half of the adults in the United States use supplements. Most of the supplements contain pharmaceutically active botanicals, which can have adverse side effects.’

A total of 37,958 adults were included in the study (average age, 46 years; women, 52 percent), with a response rate of 74 percent. Overall, the use of supplements remained stable between 1999 and 2012, with 52 percent of U.S. adults reporting the use of any supplements in 2011-2012. Use of MVMM decreased, with 37 percent reporting use in 1999-2000 and 31 percent reporting use in 2011-2012. Vitamin D supplementation from sources other than MVMM increased from 5.1 percent to 19 percent and use of fish oil supplements increased from 1.3 percent to 12 percent over the study period, whereas use of a number of other supplements decreased, including vitamins C, E, and selenium.




Trends varied across age, sex, race/ethnicity, and education.
"With the present data, it is clear that the use of supplements among U.S. adults has stabilized. This stabilization appears to be the balance of several opposing trends, with a major contributing downward factor being the decrease in use of MVMM," the authors write.
"What are the conclusions from this new analysis? It is now well documented that more than half of U.S. adults use supplements. Physicians should include supplements when they review medications with all patients and also consider supplements when symptoms raise the possibility of a supplement-related adverse effect. It is now known that many supplements contain pharmaceutically active botanicals, which can have important clinical effects," writes Pieter A. Cohen, M.D., of the Cambridge Health Alliance, Cambridge, and Harvard Medical School, Boston, in an accompanying editorial.
"For example, red yeast rice, yohimbe, and caffeine all have pharmacological effects, and although ephedra has been banned, a variety of synthetic drugs have replaced ephedra as stimulants in many sports and weight loss supplements. Reporting suspected adverse effects of supplements is also critical. The FDA relies on physicians and consumers to report adverse events via MedWatch to remove hazardous supplements from the marketplace."
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The study is published in JAMA.
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