The most common ma-lignant primary brain tumor in adults is glioblastoma.
The aggressive growth manner, characterized by marked angiogenesis and extensive tumor cell invasion into normal brain parenchyma with frequent formation of tumor microsatellites at distal sites, makes eradication impossible even after extensive microsurgical resection combined with current standard chemoradiation and adjuvant temozolomide.
Inflammatory Protein Converts Glioblastoma Cells into Untreatable Form
A prominent protein activated by inflammation is the key instigator that converts glioblastoma multiforme cells to their most aggressive, untreatable form and promotes resistance to radiation therapy.
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Thus, novel therapeutic strategies must to be investigated for the development of a more effective treatment strategy. Stem cell-based therapies are emerging as novel cell-based delivery vehicle for therapeutic agents.
Prof. Qingjun Zhang and team from the Department of Neurosurgery, Peking University People's Hospital proposed that umbilical cord mesenchymal stem cells may have similar targeting capabilities for glioma.
![Cell Maturity Pathway is Deleted or Weak in Glioblastoma Multiforme: Scientists]( "Cell Maturity Pathway is Deleted or Weak in Glioblastoma Multiforme: Scientists")
Scientists report that a program that pushes immature cells to grow up and fulfill their destiny as useful, dedicated cells is short-circuited in the most common and deadly form of brain tumor.
The researchers found that human umbilical cord mesenchymal stem cells demonstrated excellent glioma-specific targeting capacity in established rat glioma models after intratumoral injection or contralateral ventricular administration in vivo. These findings were published in the Neural Regeneration Research (Vol. 8, No. 22, 2013).
Source: Eurekalert
Cell Maturity Pathway is Deleted or Weak in Glioblastoma Multiforme: Scientists
Scientists report that a program that pushes immature cells to grow up and fulfill their destiny as useful, dedicated cells is short-circuited in the most common and deadly form of brain tumor.
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The researchers found that human umbilical cord mesenchymal stem cells demonstrated excellent glioma-specific targeting capacity in established rat glioma models after intratumoral injection or contralateral ventricular administration in vivo. These findings were published in the Neural Regeneration Research (Vol. 8, No. 22, 2013).
Source: Eurekalert
Poliovirus Vaccine Trial for Recurrent Glioblastoma Reveals Promising Results
Researchers at Duke Cancer Institute report that an attack on glioblastoma brain tumor cells that uses a modified poliovirus is showing encouraging results in an early study.
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 Researchers: Novel Combination Therapy Shuts Down Escape Route, Killing Glioblastoma Tumor CellsGlioblastoma is the most common and lethal form of brain tumor in adults. | Advertisement
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