About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Therapeutic HIV Vaccine is Not Effective: Clinical Trial

by Hannah Joy on December 11, 2017 at 3:09 PM
Font : A-A+

Therapeutic HIV Vaccine is Not Effective: Clinical Trial

A therapeutic HIV vaccine was found to have no effect on suppressing HIV in the absence of antiretroviral therapy (ART), reveals a new study.

A randomized, double-blind, placebo-controlled clinical trial found no benefit, but could offer researchers much needed insights for future cure efforts. The authors say their results represent yet another addition to the burgeoning body of evidence to suppress HIV.

Advertisement


Although ART has provided tremendous benefits for prolonging lifespans of those infected with HIV, the regimens have not been able to eliminate the virus from its reservoirs within the body.

Therapeutic vaccination has emerged as a potential strategy to boost people's own immune responses against HIV so they can control the virus without ART.
Advertisement

To study the effectiveness of such an approach, Michael Sneller, Anthony Fauci and colleagues recruited a cohort of HIV-infected individuals from the United States and Canada who had initiated ART shortly after their initial diagnosis.

During a 36-week period where all participants continued ART treatment, 14 people received four injections of a therapeutic HIV vaccine and 15 individuals were administered saline as a control.

When ART was discontinued for 16 weeks under the supervision of the researchers, there was no difference observed in viral rebound between placebo and vaccine groups.

Surprisingly, four people in the placebo group exhibited spontaneous HIV suppression - a substantially greater proportion than would be predicted by the estimated prevalence of so-called "elite HIV controllers" in the general population.

A related Focus by Nelson Michael discusses how these findings further demonstrate the value and importance of well-designed placebo-controlled trials.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Oral Health And AIDS AIDS/HIV AIDS/HIV - Epidemiology AIDS/HIV - Clinical Features AIDS/HIV - Health Education AIDS/HIV - Prevention And Transmission AIDS / HIV - Treatment AIDS/HIV- Lab Tests and Faqs Clinical Trials Clinical Trials - The Past and The Future 

Recommended Reading
Feuding Antibodies Blocked High-profile HIV Vaccine Trial
A high-profile HIV vaccine trial that was shown to work in just under a third of patients may have ....
Complex Protein may Help HIV Vaccine Development
Scientists at Duke University have taken aim at what may be an Achilles' heel of the HIV virus....
In Infants, HIV Vaccines Elicit Immune Response
A new analysis of two HIV vaccine trials that involved pediatric patients shows that the ......
New HIV Vaccine Candidate Molecule Developed
A new sugar-protein molecule elicits a good immune response against the HIV virus in rabbits, and .....
AIDS / HIV - Treatment
Encyclopedia section of medindia explains in brief about the treatment for AIDS/HIV...
AIDS/HIV
"AIDS is an epidemic disease, a potentially preventable, deadly infection for which there is no cure...
AIDS/HIV - Clinical Features
Encyclopedia section of medindia gives general info about HIV Clinical Features...
AIDS/HIV - Epidemiology
AIDS or HIV is an epidemic disease, a potentially deadly infection that can be prevented with preca...
AIDS/HIV - Health Education
Encyclopedia section of medindia gives general info about AIDS information and health education....
AIDS/HIV - Prevention And Transmission
Encyclopedia section of medindia explains in brief about the prevention for AIDS/HIV...
Clinical Trials
Clinical trials are experiments that yield useful information to clinicians if a particular treatmen...
Clinical Trials - The Past and The Future
Many of the drugs that are used today have been discovered by chance or often by mere serendipity...
Oral Health And AIDS
AIDS has taken on massive proportions in modern times. It is estimated that over 15 million people a...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use