Subcutaneous Therapy For Breast Cancer

The world's first subcutaneous treatment launched in India effectively reduces breast cancer treatment time by a massive 90 percent.

The world’s first subcutaneous treatment launched in India effectively reduces breast cancer treatment time by a massive 90 percent.

The treatment by Roche called PHESGO is the first-ever fixed-dose formulation in oncology that combines two monoclonal antibodies: Perjeta (pertuzumab) and Herceptin (trastuzumab) with hyaluronidase.

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The drug is administered via an under-the-skin injection in combination with intravenous (IV) chemotherapy to treat early and metastatic HER2-positive breast cancer.

Roche, in a statement, said that it had combined two monoclonal antibodies that a single SC injection can administer.

The single-dose jab takes a few minutes compared to hours with IV formulations for each round of treatment, thus reducing chair time for patients by 90 percent.

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It also provides a faster, more convenient, and less invasive means to receive breast cancer therapy.

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PHESGO was first approved by the US Food and Drug Administration (FDA) in June 2020 and the European Medicines Agency (EMA) in December 2020 and also has been recognized in the NCCN treatment guidelines.

In India, PHESGO was approved by the DCGI in October 2021, and the import license was granted in January 2022.

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Globally, over 17,000 breast cancer patients have benefited from PHESGO as of December 2021, Roche said.

As per the phase II study, 85 percent of people receiving treatment for HER2-positive breast cancer preferred treatment with PHESGO compared to IV administration due to less time in the clinic and more comfortable treatment administration.

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"PHESGO is a pathbreaking drug that will provide convenience and improve the quality of life of patients suffering from breast cancer by significantly reducing the in-clinic time for them," Roche Pharma India CEO and Managing Director V. Simpson Emmanuel said in a statement.

Source-IANS