A new MIT study has found that there are two brain circuits involved in habitual learning.
The study also found that patterns of activity in these circuits evolve as our behaviours become more habitual.
Dyscalculia / Learning Disabilities
Dyscalculia is a learning disability involving mathematics. Recognized by The WHO, it affects nearly 4 - 7% of the world population. If you have dyscalculia it tends to affect every aspect of your life.
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The researchers focused on the basal ganglia-brain structures that are best known for their role in movement control, but which are also involved in emotion, cognition and reward-based learning.
These different functions are thought to reside in different parts of basal ganglia. The dorsolateral part of the striatum (the input side of the basal ganglia) controls movement and is connected to the sensorimotor cortex, while the dorsomedial striatum controls flexible behaviour and is connected to higher areas known as association cortex.
![Scientists Identify Brain Receptor Behind Learning Deficits Post-Puberty]( "Scientists Identify Brain Receptor Behind Learning Deficits Post-Puberty")
Scientists have named a novel brain receptor, alpha4-beta-delta, as the culprit behind learning deficits that come with puberty.
But it has not been clear how these distinct circuits contribute to the learning of new behaviours.
Now for first time, researchers at MIT have recorded the activity of these two circuits in rats as they learned to navigate a maze, and found that the circuits have distinct patterns of activity that evolve during the course of learning.
The team led by Ann Graybiel recorded the activity of thousands of neurons in the striatum as rats learned to find a cache of chocolate sprinkles at the end of a maze.
As they approached a T-junction in the maze, the rats had to decide whether to turn right or left.
The correct direction was indicated by a sound or a touch cue, the meaning of which the rats had to discover through trial-and-error.
And just like human commuters, the rats performed this over and over again until the correct choice became routine.
As the rats' performance improved with repetition, the two different striatal circuits showed distinct patterns of activity.
The dorsolateral striatal neurons were most active at the specific action points within the maze (start, stop, turn etc) and this pattern became steadily stronger with practice.
The dorsomedial neurons, by contrast, showed highest activity around the decision period-when the rat experienced the cue and had to decide which way to turn.
These neurons were also most active as the rats were learning, and their activity declined in later trials once the rats had mastered the task.
"We think the two basal ganglionic circuits must work in parallel. We see what looks like competition between the two circuits until the learned behaviour becomes ingrained as a habit," said Catherine Thorn, first author of the study.
"These brain circuits are affected in Parkinson's disease, substance abuse and many psychiatric disorders. If we can learn how to tilt the competition in one direction or the other, we might help bring new focus to existing therapies, and possibly aid in the development of new therapies," said Graybiel.
But in terms of every day life, "it is good to know that we can train our brains to develop good habits and avoid bad ones," added Graybiel.
Source: ANI
Scientists Identify Brain Receptor Behind Learning Deficits Post-Puberty
Scientists have named a novel brain receptor, alpha4-beta-delta, as the culprit behind learning deficits that come with puberty.
Advertisement
But it has not been clear how these distinct circuits contribute to the learning of new behaviours.
Now for first time, researchers at MIT have recorded the activity of these two circuits in rats as they learned to navigate a maze, and found that the circuits have distinct patterns of activity that evolve during the course of learning.
The team led by Ann Graybiel recorded the activity of thousands of neurons in the striatum as rats learned to find a cache of chocolate sprinkles at the end of a maze.
As they approached a T-junction in the maze, the rats had to decide whether to turn right or left.
The correct direction was indicated by a sound or a touch cue, the meaning of which the rats had to discover through trial-and-error.
And just like human commuters, the rats performed this over and over again until the correct choice became routine.
As the rats' performance improved with repetition, the two different striatal circuits showed distinct patterns of activity.
The dorsolateral striatal neurons were most active at the specific action points within the maze (start, stop, turn etc) and this pattern became steadily stronger with practice.
The dorsomedial neurons, by contrast, showed highest activity around the decision period-when the rat experienced the cue and had to decide which way to turn.
These neurons were also most active as the rats were learning, and their activity declined in later trials once the rats had mastered the task.
"We think the two basal ganglionic circuits must work in parallel. We see what looks like competition between the two circuits until the learned behaviour becomes ingrained as a habit," said Catherine Thorn, first author of the study.
"These brain circuits are affected in Parkinson's disease, substance abuse and many psychiatric disorders. If we can learn how to tilt the competition in one direction or the other, we might help bring new focus to existing therapies, and possibly aid in the development of new therapies," said Graybiel.
But in terms of every day life, "it is good to know that we can train our brains to develop good habits and avoid bad ones," added Graybiel.
Source: ANI
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