Some unhealthy gene mutations can be corrected with diet, according to scientists. The new research report appears in the April 2012 issue of the journal GENETICS (http://www.genetics.org/). Researchers from the University of California, Berkeley, determined variations and responses to vitamin treatment in the human cystathionine beta synthase gene, which when defective, causes the disease homocystinuria, an inherited metabolic disorder sometimes treatable with vitamin B6. After the analysis, scientists correlated specific gene mutations with severity of the disease, ranging from perfectly healthy and functional to severe and untreatable. Although the current study focused on homocystinuria, testing the effects of naturally occurring gene variations using surrogate organism genetics can be applied to other inherited disorders, such as neural tube defect, cleft palate, and blindness. "The era of personal genome sequences is upon us, but there is a growing gap between the ability to sequence human genomes and the ability to understand the significance of variation in genome sequences," said Jasper Rine, Ph.D., the principal investigator of this research in the Department of Molecular and Cell Biology at the California Institute of Quantitative Biosciences at the University of California, Berkeley. "This study demonstrates one way to close the gap; the data separate gene variants into distinct classes, including a group amenable to dietary intervention." To make their determination, scientists "swapped" the cystathionine beta synthase gene of baker's yeast with the gene from humans to test which variants were healthy, treatable, or untreatable with additional vitamin B6. As a result, the study clarified the function of 84 DNA sequence variants in this gene, which will help physicians more effectively treat patients based on their particular genotypes. In addition, this approach opens doors for future studies examining other human genes that similarly cross over between humans and yeast. "We may have the DNA sequence of the human genome, but we're still trying to figure out what it means," said Mark Johnston, Editor-in-Chief of the journal GENETICS. "This study moves us a step closer toward better understanding the genetic variability among people. More immediately, knowledge of these gene mutations will help physicians prescribe treatment based on genotype rather than outward symptoms or trial and error." Source: Eurekalert << Disease Modeling and Transplant Studies may be Helped by Ne... Scientists Discover Genetic Regulator of Fat Metabolism >> Recommended Reading Genetic Testing of Diseases Genetic testing helps to confirm a genetic condition in an individual and involves q complex laboratory techniques READ MORE Genetic Counseling Encyclopedia section of medindia gives general info about Genetic counseling READ MORE Epigenetics In the recent years 'epigenetics' represents inheritable changes in gene expression that do not include DNA alterations. READ MORE Bulimia Nervosa The term ''Bulimia'' refers to episodes of uncontrolled excessive eating, known as "binges," followed by self-induced vomiting or purgation. READ MORE Cystic Fibrosis Cystic fibrosis is a genetic disease involving the mucus and sweat glands and the medical world has still to find its cure READ MORE Diet Pills Diet pills are flooding the market by millions. The positive side of diet pills to most people is that they achieve their objective of losing weight. Medical reviews are against the use of diet pills. READ MORE DNA Finger Printing DNA fingerprinting is a technique which helps forensic scientists and legal experts solve crimes, identity thefts, legal suits and terrorism cases. READ MORE Lifestyle Modification: No Big Deal! Simple and practically possible lifestyle changes can make a huge difference in improving our health status without actually putting much effort. READ MORE Macrobiotic Diet Macrobiotics is an Oriental theory that lays down guidelines for promoting wellbeing and longevity through systematic diet consisting mainly of whole grains and beans. READ MORE Negative Calorie Diet The History of dieting probably dates back to the year 1807. It was believed that King William suddenly felt the urge to lose weight after he found it difficult to ride his horse due to weight gain. READ MORE The Cabbage Diet The plausible reason that can be sited is the inherent low calorie property of cabbage. READ MORE Why Do We Eat - Nutrition Facts The importance of eating food and the physiological, psychological and social functions of food. READ MORE Most Popular on Medindia Pregnancy Confirmation Calculator A-Z Drug Brands in India Vent Forte (Theophylline) More News on: Diet PillsDNA Finger PrintingThe Cabbage DietNegative Calorie DietBulimia NervosaWhy Do We Eat - Nutrition FactsDiet Lifestyle and Heart DiseaseCystic FibrosisMacrobiotic DietLifestyle Modification: No Big Deal!