![Safer, Natural Skin Whitening Cream, Sans Side Effects, In the Offing
Safer, Natural Skin Whitening Cream, Sans Side Effects, In the Offing](https://images.medindia.net/health-images/1200_1000/cosmetics.jpg)
Dozens of skin whitening creams, lotions, and other products are on sale throughout Asia. Some products contain toxic mercury, hydroquinone, and other potentially toxic substances that can cause redness, itching, inflammation and other skin problems. Some whitening ingredients could increase the risk of skin cancer when used frequently and at high doses, Wang said, citing the need for safer, more effective alternatives.
Wang and colleagues say that they have found a promising alternative in the form of an herbal "cure-all" used in traditional Chinese medicine in the form of soup or tea. The evergreen bush, Cinnamomum subavenium, is a close relative of the trees whose inner bark is the source of cinnamon. The scientists isolated two chemicals from the plant that have the ability to block tyrosinase, an enzyme that controls the synthesis of melanin, a dark pigment responsible for coloring skin, hair, and eyes. Inhibiting tyrosinase is one of the major strategies for skin-whitening, Wang said.
They tested these so-called "melanogenesis inhibitors" on the embryos of zebrafish, which are widely used as stand-ins for people and other animals in biomedical research. The embryos contain a highly visible band of black pigment. Exposure to low levels of the two chemicals reduced melanin production in the fish embryos by almost 50 percent within just four days, turning the embryos snowy white, the scientists said.
"When we saw the results, we were amazed," said Wang, who is with Kaohsiung Medical University in Taiwan. "My first thought was, well, ‘If these herbal whiteners can transform zebrafish embryos from black to white, maybe they can also lighten women's skin.'"
He estimated that the chemicals are 100 times more effective in reducing melanin pigmentation than the common skin whitening agents kojic acid and arbutin, which have been used in cosmetics for more than 30 years. The substances did not appear to be toxic when tested in low doses on both cultured human skin cells and zebrafish embryos, Wang noted.
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Source-Newswise