Route from One Illness to Another Mapped by Researchers

by Himabindu Venkatakrishnan on June 25, 2014 at 4:26 PM
 Route from One Illness to Another Mapped by Researchers

A big data has been analysed by researchers, for the first time, relating to an entire country's disease development. The new ground-breaking results are based on data from 6.2 million Danes who were followed for 14.9 years - using state-of-the-art systems biology, researchers have boiled down the massive amount of data to 1,171 so-called thoroughfares with central information on the course of diabetes, chronic obstructive pulmonary disease, cancer, arthritis and cardiovascular disease. The researchers are, in other words, able to forecast whether you are driving on a risky highway to hell with an acute need for rerouting to improve your health.

Data unveiling an entire life story


We can see clear correlations that have not previously been explained; a disease like gout, for example, is strongly linked to cardiovascular diseases when we look at the large data volumes and the disease networks that appear. It is a surprising correlation that researchers have been debating previously. The quicker we identify an inappropriate pattern, the better we can prevent and treat critical diseases. In the future, we will be able to predict many diseases using simple tests in combination with known disease progression patterns, says Søren Brunak, Professor at the Technical University of Denmark and the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen.

The large data volumes have been obtained from, e.g. , electronic patient records. In the long term, the clinical data can be combined with molecular data, where the researchers will map the correlations between DNA and proteins in the body and specific diseases using state-of-the-art computer technology:

Our results make it possible to view diseases in a larger context. Instead of looking at each disease in isolation, you can talk about a complex system with many different interacting factors. By looking at the order in which different diseases appear, you can start to draw patterns and see complex correlations outlining the direction for each individual person, says Anders Boeck Jensen, postdoc at the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen.

The days of 'one size fits all' are over

In the future, individualized treatment will be gaining ground, i.e. treatment that takes into account the individual patient's entire genome and proteome. Denmark is at the forefront of tailored medical treatment. Danes are a homogeneous population, and the country's unified healthcare sector, including the civil registration system, is a unique setup that makes it possible to follow patients over a lifetime:

The perspective is that your genetic profile or the total network of associated proteins in your body, your proteome, can be mapped in a few years' time, enabling you to suddenly learn things about yourself which can be used to forecast the progress of diseases over an entire lifetime. I believe in a bright future, because we can improve the quality of life and extend life in the long run - as well as save money as a society - if we offer people a more effective and targeted treatment, says Professor Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.

Professor Søren Brunak adds: - Your genetic data might find their way to your health insurance card or a database which your doctor can access. This requires, of course, thorough analysis of the data obtained from DNA and protein sequencing in the coming years.

Source: Eurekalert
Font : A-A+



Latest Research News

Life Expectancy Gap for Autistic Individuals Revealed
Diagnosed autistic individuals showed increased premature mortality in the UK, highlighting urgent needs to address associated inequalities.
Exploring How Hearing Impairment Shapes Dementia Risk
Study reveals a correlation between hearing impairment and distinct brain region variances, contributing to dementia.
Coffee and its Role in Neurodegenerative Disorders
Financial impact of caring for individuals with neurodegenerative disorders reaches hundreds of billions annually in the United States.
Healthcare Industry Struggles With Tech Skills Shortage
Experts emphasize that addressing the skills gap demands immediate attention and innovative solutions, including education, re-training, and significant time investment.
Nano-Probes Uncover Cellular Reactions to Pressure
New study unveiled the cells' ability to adapt in responses and potential implications for conditions such as diabetes and cancer.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Route from One Illness to Another Mapped by Researchers Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests