Dose dumping is the name given to a process where drugs release their contents very quickly in an unwanted manner. Controlled release pills and capsules that show a tendency in the standard laboratory test toward releasing their medicine in a faster and potentially unsafe manner in patients who have consumed alcohol should be withheld from the market until proven safe with testing in people.
That's the conclusion of a review of existing studies in the September-October issue of ACS' Molecular Pharmaceutics, a bi-monthly journal.
In the article, Hans Lennernäs analyzed the gastrointestinal factors that may contribute to dose dumping when a vulnerable formulation interacts with alcohol present in the stomach. However, these factors are highly variable and depend on individual drinking behavior, whether food is present in the stomach, and other circumstances. That makes it "almost impossible" to predict whether a patient will experience an overdose as a result of dose dumping.